Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI)
Modify Date: 2025-08-25 17:10:35
![Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI) Structure](https://image.chemsrc.com/caspic/384/309726-06-5.png)
Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI) structure
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Common Name | Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI) | ||
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| CAS Number | 309726-06-5 | Molecular Weight | 251.32600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H17N3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI)BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1]. |
| Name | 2,4,7,9-tetramethylbenzo[b][1,8]naphthyridin-5-amine |
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| Description | BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C16H17N3 |
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| Molecular Weight | 251.32600 |
| Exact Mass | 251.14200 |
| PSA | 51.80000 |
| LogP | 4.18000 |
| HS Code | 2933990090 |
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| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |