2,4,7,9-四甲基苯并[b]-1,8-萘啶-5-胺

• 常用名: 2,4,7,9-四甲基苯并[b]-1,8-萘啶-5-胺
• 英文名: Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI)
• CAS号: 309726-06-5
• 分子量: 251.32600
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₇N₃
• 熔点: N/A
• 闪点: N/A

2,4,7,9-四甲基苯并[b]-1,8-萘啶-5-胺用途

BMH-22 是一种苯并萘啶,是一种独立于 p53 功能的 RNA 聚合酶 I (Pol I) 转录抑制剂。BMH-22 导致核仁标记蛋白重组,与核仁分离一致。BMH-22 以蛋白酶体依赖性方式破坏 RPA194 的稳定性,并抑制新生 rRNA 合成和 45S rRNA 前体的表达。BMH-22 在多种肿瘤类型中显示出有效的抗癌活性。

2,4,7,9-四甲基苯并[b]-1,8-萘啶-5-胺名称

• 中文名: 2,4,7,9-四甲基苯并[b]-1,8-萘啶-5-胺
• 英文名: 2,4,7,9-tetramethylbenzo[b][1,8]naphthyridin-5-amine

2,4,7,9-四甲基苯并[b]-1,8-萘啶-5-胺生物活性

• 描述: BMH-22 是一种苯并萘啶,是一种独立于 p53 功能的 RNA 聚合酶 I (Pol I) 转录抑制剂。BMH-22 导致核仁标记蛋白重组,与核仁分离一致。BMH-22 以蛋白酶体依赖性方式破坏 RPA194 的稳定性,并抑制新生 rRNA 合成和 45S rRNA 前体的表达。BMH-22 在多种肿瘤类型中显示出有效的抗癌活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
• 参考文献:

  [1]. RPA194, rRNA synthesis, 45S Rrna, anticancerKarita Peltonen, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014 Nov;13(11):2537-46.

2,4,7,9-四甲基苯并[b]-1,8-萘啶-5-胺物理化学性质

• 分子式: C₁₆H₁₇N₃
• 分子量: 251.32600
• 精确质量: 251.14200
• PSA: 51.80000
• LogP: 4.18000
• InChIKey: ZNPSDSMZKLWRLO-UHFFFAOYSA-N
• SMILES: Cc1cc(C)c2nc3nc(C)cc(C)c3c(N)c2c1

2,4,7,9-四甲基苯并[b]-1,8-萘啶-5-胺安全信息

• 海关编码: 2933990090

2,4,7,9-四甲基苯并[b]-1,8-萘啶-5-胺海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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