Triiodothyronine sulfate

Modify Date: 2024-01-09 18:46:56

Triiodothyronine sulfate Structure
Triiodothyronine sulfate structure
Common Name Triiodothyronine sulfate
CAS Number 31135-55-4 Molecular Weight 731.04
Density N/A Boiling Point N/A
Molecular Formula C15H12I3NO7S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Triiodothyronine sulfate


Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity[1][2].

 Names

Name 3,3',5-triiodo-L-thyronine sulfate
Synonym More Synonyms

 Triiodothyronine sulfate Biological Activity

Description Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity[1][2].
Related Catalog
In Vitro Triiodothyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[2]. Liothyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. Triiodothyronine promotes growth, induces differentiation and regualtes metabolic effects[3].
References

[1]. J S LoPresti, et al. 3,5,3'-Triiodothyronine (T3) sulfate: a major metabolite in T3 metabolism in man. J Clin Endocrinol Metab. 1994 Mar;78(3):688-92.

[2]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.

[3]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.

 Chemical & Physical Properties

Molecular Formula C15H12I3NO7S
Molecular Weight 731.04
Exact Mass 730.74700
PSA 144.53000
LogP 5.20980

 Synonyms

(2S)-2-amino-3-[3,5-diiodo-4-(3-iodo-4-sulfooxyphenoxy)phenyl]propanoic acid
Liothyronine Sulfate
T3 Sulfate
Triiodothyronine sulfic acid
triiodothyronine sulfate
Triiodothyronine sulfuric ester
3,5-diiodo-O-[3-iodo-4-(sulfooxy)phenyl]-L-tyrosine