3-(3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)thiazolidine-2,4-dione structure
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Common Name | 3-(3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)thiazolidine-2,4-dione | ||
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CAS Number | 312631-87-1 | Molecular Weight | 409.28600 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C18H14Cl2N2O3S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of 3-(3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)thiazolidine-2,4-dione10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects[1][2]. |
Name | 10074-a4 |
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Synonym | More Synonyms |
Description | 10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects[1][2]. |
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Related Catalog | |
In Vitro | 10074-A4 shows inhibitory activity of HL-60 cells with an IC50 of 15.1 μM[1]. 10074-A4 (25-50 μM; 24 hours) arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells. 10074-A4 inhibits the mRNA level of the c-Myc target genes, CCND2 and CDK4[1]. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain and its binding behavior could be described as a ‘ligand cloud’. Even in the bound state, the structure of the c-Myc370-409 peptide remained a dynamic ensemble. The 10074-A4 ligand bound at different sites throughout the c-Myc370-409 chain with different strength[2]. Cell Viability Assay[1] Cell Line: HL-60 cells Concentration: 25 μM, 50 μM Incubation Time: 24 hours Result: Arrested the cell cycle at the S-phase. |
References |
Molecular Formula | C18H14Cl2N2O3S |
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Molecular Weight | 409.28600 |
Exact Mass | 408.01000 |
PSA | 87.84000 |
LogP | 4.09550 |
3-[3-(3,6-dichlorocarbazol-9-yl)-2-hydroxypropyl]thiazolidine-2,4-dione |
3-[3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl]-1,3-thiazolidine-2,4-dione |