LY-517717

Modify Date: 2025-09-17 00:30:39

LY-517717 Structure
LY-517717 structure
Common Name LY-517717
CAS Number 313489-71-3 Molecular Weight 459.58300
Density N/A Boiling Point N/A
Molecular Formula C27H33N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LY-517717


LY-517717 is a potent and orally active FXa inhibitor. LY-517717 shows antithrombotic and anticoagulant activity. LY-517717 has the potential for the research of venous thromboembolism after hip or knee replacement[1].

 Names

Name N-{(1R)-2-[4-(1-Methyl-4-piperidinyl)-1-piperazinyl]-2-oxo-1-phen ylethyl}-1H-indole-6-carboxamide

 LY-517717 Biological Activity

Description LY-517717 is a potent and orally active FXa inhibitor. LY-517717 shows antithrombotic and anticoagulant activity. LY-517717 has the potential for the research of venous thromboembolism after hip or knee replacement[1].
Related Catalog
References

[1]. Agnelli G, et al. A phase II study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromboembolism after hip or knee replacement. J Thromb Haemost. 2007 Apr;5(4):746-53.  

 Chemical & Physical Properties

Molecular Formula C27H33N5O2
Molecular Weight 459.58300
Exact Mass 459.26300
PSA 75.17000
LogP 3.26590
InChIKey VYNKVNDKAOGAAQ-RUZDIDTESA-N
SMILES CN1CCC(N2CCN(C(=O)C(NC(=O)c3ccc4cc[nH]c4c3)c3ccccc3)CC2)CC1

 LY-517717Bioassay

View more

Name: Oral bioavailability in dog
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL1273270
Name: Half life in dog
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL1273271
Name: Inhibition of factor 10a
Source: ChEMBL
Target: Coagulation factor X
External Id: CHEMBL1273257
Name: Oral bioavailability in rat
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1273275
Name: Antithrombotic activity in rat arteriovenous-shunt thrombosis model
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1273347
Name: Half life in rat
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1273276
Name: ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301366
Total 7, Current Page 1 of 1
1
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.