VU590

Modify Date: 2024-01-10 09:48:27

VU590 Structure
VU590 structure
Common Name VU590
CAS Number 313505-85-0 Molecular Weight 488.53
Density N/A Boiling Point N/A
Molecular Formula C24H32N4O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VU590


VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney[1][2].

 Names

Name 7,13-bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane,dihydrochloride
Synonym More Synonyms

 VU590 Biological Activity

Description VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney[1][2].
Related Catalog
Target

IC50: 290 nM (Kir1.1), 8 μM (Kir7.1)[1]

References

[1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.

[2]. Kharade SV, et al. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Mol Pharmacol. 2017 Sep;92(3):338-346.

 Chemical & Physical Properties

Molecular Formula C24H32N4O7
Molecular Weight 488.53
Exact Mass 560.18000
PSA 125.81000
LogP 5.39680

 Synonyms

VU 590 dihydrochloride
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