OM99-2 trifluoroacetate salt

Modify Date: 2024-01-03 05:55:55

OM99-2 trifluoroacetate salt structure	Common Name	OM99-2 trifluoroacetate salt
	CAS Number	314266-76-7	Molecular Weight	892.99200
	Density	1.311g/cm3	Boiling Point	1322.4ºC at 760mmHg
	Molecular Formula	C₄₁H₆₄N₈O₁₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	753.6ºC

Use of OM99-2 trifluoroacetate salt

OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor[2], has the potential for the research of the Alzheimer's disease[3].

Name	Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe
Synonym	More Synonyms

Description	OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor[2], has the potential for the research of the Alzheimer's disease[3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
Target	Ki: 9.58 nM (memapsin 2)
In Vitro	Memapsin 2 (BACE) is an aspartyl protease known as beta-secretase that acts on the production of the beta-amyloid peptide in the human brain[4].
References	[1]. Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. [2]. Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. [3]. Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. [4]. Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422.

Density	1.311g/cm3
Boiling Point	1322.4ºC at 760mmHg
Molecular Formula	C₄₁H₆₄N₈O₁₄
Molecular Weight	892.99200
Flash Point	753.6ºC
Exact Mass	892.45400
PSA	375.84000
LogP	2.00990
Index of Refraction	1.562

OM99-2 trifluoroacetate salt MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport

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om99-2

MFCD03787969

H-Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2