Mycophenolic Acid β-D-Glucuronide

Modify Date: 2024-01-02 16:47:40

Mycophenolic Acid β-D-Glucuronide structure	Common Name	Mycophenolic Acid β-D-Glucuronide
	CAS Number	31528-44-6	Molecular Weight	496.46100
	Density	1.502g/cm3	Boiling Point	875.7ºC at 760mmHg
	Molecular Formula	C₂₃H₂₈O₁₂	Melting Point	98-100ºC
	MSDS	N/A	Flash Point	299.6ºC
	Symbol	GHS02, GHS07	Signal Word	Danger

Use of Mycophenolic Acid β-D-Glucuronide

Mycophenolic acid glucuronide is a metabolite of the immunosuppressant mycophenolic acid (MPA). Mycophenolic acid glucuronide shows anti-tumor activity and can be used in adenocarcinoma research[1][2][3].

Name	mycophenolic acid glucuronide
Synonym	More Synonyms

Description	Mycophenolic acid glucuronide is a metabolite of the immunosuppressant mycophenolic acid (MPA). Mycophenolic acid glucuronide shows anti-tumor activity and can be used in adenocarcinoma research[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Mycophenolic acid glucuronide shows weak IMP dehydrogenase (IMPDH) type II inhibition with an IC50 of 3.3 mg/L[3].
In Vivo	Mycophenolic acid glucuronide (intraperitoneal injection; 6 mg/mouse; once two days; 6 d) treatment reduces tumor growth in an Ehrlich murine spontaneous adenocarcinoma model[2]. Animal Model: Swiss albino strain mouse implanted with Ehrlich ascites tumor cells[2] Dosage: 6 mg/mouse Administration: Intraperitoneal injection; 6 mg/mouse; once two days; 6 d Result: Showed 76.8% tumor inhibition compared to the untreated control.
References	[1]. Natascha A Wolff, et al. Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of the human kidney. Nephrol Dial Transplant. 2007 Sep;22(9):2497-503. [2]. Ando K, et al. Synthesis of mycophenolic acid beta-D-glucuronide and its antitumor activity. J Antibiot (Tokyo). 1970 Aug;23(8):408-13. [3]. Gensburger O, et al. Effect of mycophenolate acyl-glucuronide on human recombinant type 2 inosine monophosphate dehydrogenase. Clin Chem. 2009 May;55(5):986-93.

Density	1.502g/cm3
Boiling Point	875.7ºC at 760mmHg
Melting Point	98-100ºC
Molecular Formula	C₂₃H₂₈O₁₂
Molecular Weight	496.46100
Flash Point	299.6ºC
Exact Mass	496.15800
PSA	189.28000
LogP	0.29860
Index of Refraction	1.624
Storage condition	Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H302 + H312 + H332-H319
Precautionary Statements	P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235
Hazard Codes	F,Xn
Risk Phrases	11-20/21/22-36
Safety Phrases	16-26-36/37
RIDADR	UN 1648 3 / PGII

5-[(2E)-5-Carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl b-D-Glucopyranosiduronic Acid

MYCOPHENOLIC ACID B-D-GLUCURONIDE

Mycophenolic Acid-D-Glucuronide

Mycophenolic Acid Glucosiduronate

5-[(2E)-5-Carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl-D-Glucopyranosiduronic Acid

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: MYCOPHENOLIC ACID GLUCURONIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Mycophenolic Acid β-D-Glucuronide

Use of Mycophenolic Acid β-D-Glucuronide

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Mycophenolic Acid β-D-Glucuronide Biological Activity

Chemical & Physical Properties

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