Haloxon

Modify Date: 2026-07-01 17:10:11

Haloxon Structure
Haloxon structure
Common Name Haloxon
CAS Number 321-55-1 Molecular Weight 415.59000
Density 1.5g/cm3 Boiling Point 504.6ºC at 760 mmHg
Molecular Formula C14H14Cl3O6P Melting Point N/A
MSDS USA Flash Point 438.8ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Haloxon


Haloxon is an organophosphorus anthelmintic once used against nematodes of the abomasum and small intestine in ruminants.

Summary: Haloxon (Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosphate, CAS 321-55-1, molecular formula C14H14Cl3O6P, molecular weight 415.59000) is an antiparasitic (nematode) compound. For research-use only, not for medical or clinical usage.


 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate
Synonym More Synonyms

 Haloxon Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Haloxon is an organophosphorus anthelmintic once used against nematodes of the abomasum and small intestine in ruminants.
Related Catalog

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.5g/cm3
Boiling Point 504.6ºC at 760 mmHg
Molecular Formula C14H14Cl3O6P
Molecular Weight 415.59000
Flash Point 438.8ºC
Exact Mass 413.95900
PSA 84.78000
LogP 4.75250
Index of Refraction 1.561
InChIKey KULDXINYXFTXMO-UHFFFAOYSA-N
SMILES Cc1c(Cl)c(=O)oc2cc(OP(=O)(OCCCl)OCCCl)ccc12
Storage condition 2-8℃

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN5250000
CHEMICAL NAME :
Coumarin, 3-chloro-7-hydroxy-4-methyl-, bis(2-chloroethyl) phosphate
CAS REGISTRY NUMBER :
321-55-1
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C14-H14-Cl3-O6-P
MOLECULAR WEIGHT :
415.60
WISWESSER LINE NOTATION :
T66 BOVJ DG E1 IOPO&O2GO2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
>7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
763 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Cells - not otherwise specified
DOSE/DURATION :
10 mg/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 10,143,1982 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 10,85,1974

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302 + H332-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
RIDADR NONH for all modes of transport
RTECS GN5250000
HS Code 2932209090

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles18

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Effects of selected organophosphate insecticides on serum cholinesterase isoenzyme patterns in the rat.

Vet. Hum. Toxicol. 38(3) , 196-9, (1996)

The serum cholinesterase (ChE) isoenzyme in rats shows 6 bands after polyacrylamide gradient gel electrophoresis. The effects of organophosphates (fenthion, chlorpyrifos, diazinon, bromophos, propapho...

Effect of some anthelmintics on malate dehydrogenase activity and mortality in two avian nematodes Ascaridia galli and Heterakis gallinae.

Angew. Parasitol. 27(3) , 175-80, (1986)

Cambendazole and tiabendazole at 10(-4) M concentrations caused mortality in both the parasites after 10 min and 20 min, respectively. H. gallinae was killed by 10(-4) M haloxon but A. galli remained ...

Effect of cambendazole and haloxon on the carbohydrate metabolism of Ascaridia galli and Heterakis gallinae (Nematoda).

Angew. Parasitol. 31(2) , 101-5, (1990)

Cambendazole 10(-4) M significantly reduced the level of glycogen in both the parasites. Lactic acid level was found enhanced. Oxygen consumption was suppressed by 63 and 94% in A. galli and H. gallin...

 HaloxonBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2-Ethylhexyl 4,4-bis(3-butoxy-3-oxopropyl)-10-ethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate
di(2-butoxycarbonylethyl)tin S,S'-bis-(2-ethylhexyl thioglycolate)
Di-(2-chlorethyl)-3-chloro-4-methylcoumarin-7-yl-phosphat
8-Oxa-3,5-dithia-4-stannatetradecanoicacid,4,4-bis(3-butoxy-3-oxopropyl)-10-ethyl-7-oxo-,2-ethylhexyl ester
Haloxon

 Haloxon | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the storage conditions for Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate?
A: Storage conditions for Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate: 2-8℃.
Q: What is the English name of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate?
A: The English name of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate is Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate.
Q: What is the boiling point of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate?
A: Boiling point of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate is 504.6ºC at 760 mmHg.
Q: What is the CAS number of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate?
A: CAS number of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate is 321-55-1.
Q: What is the SMILES notation of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate?
A: SMILES notation of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate is Cc1c(Cl)c(=O)oc2cc(OP(=O)(OCCCl)OCCCl)ccc12.
Q: What is the InChIKey of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate?
A: InChIKey of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate is KULDXINYXFTXMO-UHFFFAOYSA-N.
Q: What is the Chinese name of 321-55-1?
A: Chinese name of 321-55-1 is Haloxon.
Q: What is the molecular weight of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate?
A: Molecular weight of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate is 415.59000.
Q: What are the uses of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate?
A: Main uses of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate: Haloxon is an organophosphorus anthelmintic once used against nematodes of the abomasum and small intestine in ruminants.
Q: What is the polar surface area (PSA) of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate?
A: Polar surface area (PSA) of Bis(2-chloroethyl) 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl phosph ate is 84.78000.

 Haloxonfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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