SCH 221510
Modify Date: 2025-10-09 12:02:50
SCH 221510 structure
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Common Name | SCH 221510 | ||
|---|---|---|---|---|
| CAS Number | 322473-89-2 | Molecular Weight | 397.55 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H31NO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SCH 221510SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect[1]. |
| Name | 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol |
|---|---|
| Synonym | More Synonyms |
| Description | SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect[1]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 12 nM (NOP)[1] |
| References |
| Molecular Formula | C28H31NO |
|---|---|
| Molecular Weight | 397.55 |
| Exact Mass | 397.24100 |
| PSA | 23.47000 |
| LogP | 5.84530 |
| InChIKey | LOSJNRBXNQTUNT-UHFFFAOYSA-N |
| SMILES | Cc1ccccc1C(c1ccccc1C)N1C2CCC1CC(O)(c1ccccc1)C2 |
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~%
SCH 221510 CAS#:322473-89-2 |
| Literature: Ho, Ginny D.; Anthes, John; Bercovici, Ana; Caldwell, John P.; Cheng, Kuo-Chi; Cui, Xiaoming; Fawzi, Ahmad; Fernandez, Xiomara; Greenlee, William J.; Hey, John; Korfmacher, Walter; Lu, Sherry X.; McLeod, Robbie L.; Ng, Fay; Torhan, April Smith; Tan, Zheng; Tulshian, Deen; Varty, Geoffrey B.; Xu, Xiaoying; Zhang, Hongtao Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 9 p. 2519 - 2523 |
| Precursor 1 | |
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| DownStream 0 | |
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Name: This assay (PMID: 37558952) monitors the impact of a chemical compound on general aut...
Source: ChEMBL
Target: TERT-RPE1
External Id: CHEMBL5724699
|
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Name: This assay (PMID: 37558952) monitors the impact of a chemical compound on general aut...
Source: ChEMBL
Target: U2OS
External Id: CHEMBL5724701
|
|
Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802
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|
Name: This assay (PMID: 37558952) monitors the impact of a chemical compound on ER-phagy fl...
Source: ChEMBL
Target: U2OS
External Id: CHEMBL5724700
|
|
Name: Thermal Shift Assay. Domain: start/stop: M626-G746
Source: ChEMBL
Target: Peregrin
External Id: CHEMBL5062024
|
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Name: Human kappa receptor (Opioid receptors)
Source: IUPHAR-DB
Target: kappa receptor (Opioid receptors) [Homo sapiens]
External Id: 318_Human
|
|
Name: Thermal Shift Assay. Domain: start/stop: M26-R383
Source: ChEMBL
Target: Glycogen synthase kinase-3 beta
External Id: CHEMBL5065589
|
|
Name: Thermal Shift Assay. Domain: start/stop: S229-K512
Source: ChEMBL
Target: Tyrosine-protein kinase ABL1
External Id: CHEMBL5060015
|
|
Name: GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce...
Source: ChEMBL
Target: N-formyl peptide receptor 2
External Id: CHEMBL5209827
|
|
Name: GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce...
Source: ChEMBL
Target: N-formyl peptide receptor 2
External Id: CHEMBL5209826
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| MM 77 dihydrochloride |
| 3-Endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol |
| SCH 221510 |