SU11652
Modify Date: 2024-01-31 17:14:15
SU11652 structure
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Common Name | SU11652 | ||
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| CAS Number | 326914-10-7 | Molecular Weight | 414.93 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H27ClN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SU11652SU11652 is a potent receptor tyrosine kinase (RTK) inhibitor. SU11652 also inhibits several members of the split kinase family of RTKs, including VEGFR, FGFR, PDGFR, and Kit. SU11652 can be uesd for spontaneous cancers expressing Kit mutations research[1]. |
| Name | 5-[(5-chloro-2-oxo-1H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide |
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| Synonym | More Synonyms |
| Description | SU11652 is a potent receptor tyrosine kinase (RTK) inhibitor. SU11652 also inhibits several members of the split kinase family of RTKs, including VEGFR, FGFR, PDGFR, and Kit. SU11652 can be uesd for spontaneous cancers expressing Kit mutations research[1]. |
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| Related Catalog | |
| Target |
IC50: 0.01 μM (PDGFR), 0.03 μM (Flk-1), 0.05 μM (c-kit)[1] |
| In Vitro | SU11652 (0-1 μM, 0-72 h) inhibits the growth of mast cell lines expressing mutant Kit[1]. SU11652 (0-1 μM, 0-72 h) induces cell cycle arrest followed by apoptosis in cell lines expressing mutant Kit[1]. |
| References |
| Molecular Formula | C22H27ClN4O2 |
|---|---|
| Molecular Weight | 414.93 |
| Exact Mass | 414.18200 |
| PSA | 77.23000 |
| LogP | 4.37810 |
| in1074 |