5-methyl-2-thiouridine
5-methyl-2-thiouridine structure
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Common Name | 5-methyl-2-thiouridine | ||
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| CAS Number | 32738-09-3 | Molecular Weight | 274.29 | |
| Density | 1.63g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H14N2O5S | Melting Point | 216-219 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of 5-methyl-2-thiouridine5-Methyl-2-thiouridine (2-Thio-5-methyluridine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
Summary: Chinese name: 5-甲基-2-硫脲啶, English name: 5-methyl-2-thiouridine, CAS number: 32738-09-3, molecular formula: C10H14N2O5S, molecular weight: 274.29. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 5-methyl-2-thiouridine |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 5-Methyl-2-thiouridine (2-Thio-5-methyluridine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.63g/cm3 |
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| Melting Point | 216-219 °C |
| Molecular Formula | C10H14N2O5S |
| Molecular Weight | 274.29 |
| Exact Mass | 274.06200 |
| PSA | 140.06000 |
| Index of Refraction | 1.703 |
| InChIKey | SNNBPMAXGYBMHM-JXOAFFINSA-N |
| SMILES | Cc1cn(C2OC(CO)C(O)C2O)c(=S)[nH]c1=O |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
| HS Code | 2934999090 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
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| DownStream 0 | |
CAS#:75921-08-3
CAS#:7408-41-5This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Molecular mechanism of codon recognition by tRNA species with modified uridine in the first position of the anticodon.
Proc. Natl. Acad. Sci. U. S. A. 82 , 4905-4909, (1985) Proton NMR analyses have been made to elucidate the conformational characteristics of modified nucleotides as found in the first position of the anticodon of tRNA [derivatives of 5-methyl-2-thiouridin... |
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CD spectra of 5-methyl-2-thiouridine in tRNA-Met-f from an extreme thermophile.
Nucleic Acids Res. 3 , 1703-1713, (1976) 5-Methyl-2-thiouridine (S) in tRNA-Met-f from an extreme thermophile is located in the TpsiC region, replacing T, and has a positive CD band centered at 310 nm. Upon heating, the profiles of the chang... |
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Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines.
Nucleic Acids Res. 33 , 5297-5307, (2005) Substitution of oxygen atoms by sulfur at various locations in the nucleic acid framework has led to analogs such as the DNA phosphorothioates and 4'-thio RNA. The phosphorothioates are excellent mimi... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 2-Sulfamyl-4-methyl-phenyl-thioharnstoff |
| 5-Methyl-2-thio-uridin |
| 5-methyl-2-thioureido-benzenesulfonamide |
| 5-Methyl-1-pentofuranosyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone |
| 4-Methyl-2-sulphamylphenylthiourea |
| Benzenesulfonamide,2-[(aminothioxomethyl)amino]-5-methyl |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the melting point of 5-methyl-2-thiouridine? |
| A: Melting point of 5-methyl-2-thiouridine is 216-219 °C. |
| Q: What is the molecular weight of 5-methyl-2-thiouridine? |
| A: Molecular weight of 5-methyl-2-thiouridine is 274.29. |
| Q: What is the CAS number of 5-methyl-2-thiouridine? |
| A: CAS number of 5-methyl-2-thiouridine is 32738-09-3. |
| Q: What is the English name of 5-methyl-2-thiouridine? |
| A: The English name of 5-methyl-2-thiouridine is 5-methyl-2-thiouridine. |
| Q: What is the molecular formula of 5-methyl-2-thiouridine? |
| A: Molecular formula of 5-methyl-2-thiouridine is C10H14N2O5S. |
| Q: What is the InChIKey of 5-methyl-2-thiouridine? |
| A: InChIKey of 5-methyl-2-thiouridine is SNNBPMAXGYBMHM-JXOAFFINSA-N. |
| Q: What are the upstream materials of 5-methyl-2-thiouridine? |
| A: Related upstream materials(CAS) of 5-methyl-2-thiouridine: 75921-08-3;7408-41-5. |
| Q: What is the polar surface area (PSA) of 5-methyl-2-thiouridine? |
| A: Polar surface area (PSA) of 5-methyl-2-thiouridine is 140.06000. |
| Q: What are the uses of 5-methyl-2-thiouridine? |
| A: Main uses of 5-methyl-2-thiouridine: 5-Methyl-2-thiouridine (2-Thio-5-methyluridine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
| Q: What English synonyms does 5-methyl-2-thiouridine have? |
| A: English synonyms of 5-methyl-2-thiouridine: 2-Sulfamyl-4-methyl-phenyl-thioharnstoff, 5-Methyl-2-thio-uridin, 5-methyl-2-thioureido-benzenesulfonamide, 5-Methyl-1-pentofuranosyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone, 4-Methyl-2-sulphamylphenylthiourea, Benzenesulfonamide,2-[(aminothioxomethyl)amino]-5-methyl. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |