Ibrutinib deacryloylpiperidine

Modify Date: 2024-01-01 18:58:34

Ibrutinib deacryloylpiperidine structure	Common Name	Ibrutinib deacryloylpiperidine
	CAS Number	330786-24-8	Molecular Weight	303.318
	Density	1.4±0.1 g/cm3	Boiling Point	577.4±50.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₃N₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	303.0±30.1 °C

Use of Ibrutinib deacryloylpiperidine

Ibrutinib deacryloylpiperidine (IBT4A) is an impurity of Ibrutinib[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2].

Name	3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Synonym	More Synonyms

Description	Ibrutinib deacryloylpiperidine (IBT4A) is an impurity of Ibrutinib[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
References	[1]. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES. [2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

Description

Ibrutinib deacryloylpiperidine (IBT4A) is an impurity of Ibrutinib[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

References

[1]. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES.

[2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

Density	1.4±0.1 g/cm3
Boiling Point	577.4±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₃N₅O
Molecular Weight	303.318
Flash Point	303.0±30.1 °C
Exact Mass	303.112000
PSA	89.71000
LogP	3.01
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.734
Storage condition	2-8°C