(Z)-Thiothixene

Modify Date: 2025-08-26 13:07:15

(Z)-Thiothixene Structure
(Z)-Thiothixene structure
 Common Name (Z)-Thiothixene
CAS Number 3313-26-6 Molecular Weight 443.62500
Density 1.269 g/cm3 Boiling Point 599ºC at 760 mmHg
Molecular Formula C23H29N3O2S2 Melting Point 114-118ºC
MSDS N/A Flash Point 316.1ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of (Z)-Thiothixene


(Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1.

 Names

Name cis-Thiothixene N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide
Synonym More Synonyms

 (Z)-Thiothixene Biological Activity

Description (Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1.
Related Catalog
Target

serotonergic receptor[1]

In Vitro (Z)-Thiothixene is capable of promoting cell survival and/or plasticity, and/or inhibiting cell death, especially when a toxic agent is exposed to the cells, including neuronal cells[1]. (Z)-Thiothixene is a Z (cis) isomer of thiothixene, as well as synthetic precursor and degradant[2].
References

[1]. Illana Gozes, et al. Novel compounds and methods for inhibiting cell death. US 20150141345 A1.

[2]. Severin G. Comprehensive high-performance liquid chromatographic methodology for the determination of thiothixene in bulk drug, finished product, and dissolution testing samples. J Pharm Sci. 1987 Mar;76(3):231-4.

 Chemical & Physical Properties

Density 1.269 g/cm3
Boiling Point 599ºC at 760 mmHg
Melting Point 114-118ºC
Molecular Formula C23H29N3O2S2
Molecular Weight 443.62500
Flash Point 316.1ºC
Exact Mass 443.17000
PSA 77.54000
LogP 4.42730
Index of Refraction 1.643
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XO1420000
CHEMICAL NAME :
Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene )-, (Z)-
CAS REGISTRY NUMBER :
3313-26-6
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C23-H29-N3-O2-S2
MOLECULAR WEIGHT :
443.67
WISWESSER LINE NOTATION :
T C666 BS IYJ FSWN1&1 IU3- AT6N DNTJ D1 -C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 12,142,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,17,1970

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Hazard Codes Xn: Harmful;
Risk Phrases R22
RIDADR NONH for all modes of transport
RTECS XO1420000

 Synonyms

Thiothixene
MFCD00079574
N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide
cis-Thiothixene
(Z)-Thiothixene
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