6-Carboxyfluorescein Diacetate

Modify Date: 2024-01-12 00:23:00

6-Carboxyfluorescein Diacetate Structure
6-Carboxyfluorescein Diacetate structure
 Common Name 6-Carboxyfluorescein Diacetate
CAS Number 3348-03-6 Molecular Weight 460.389
Density 1.6±0.1 g/cm3 Boiling Point 701.6±60.0 °C at 760 mmHg
Molecular Formula C25H16O9 Melting Point 152–153°C
MSDS Chinese USA Flash Point 245.1±26.4 °C

 Use of 6-Carboxyfluorescein Diacetate


6-CFDA is fluorescent polyanionic probe, and its derivatives such as 2′,7′-bis (2-carboxyethyl)-5(6)-carboxyfluorescein are used to measure changes in intracellular pH (pHi) and processes such as dendrimer aggregation and absorption.

 Names

Name 6-carboxyfluorescein diacetate
Synonym More Synonyms

 6-Carboxyfluorescein Diacetate Biological Activity

Description 6-CFDA is fluorescent polyanionic probe, and its derivatives such as 2′,7′-bis (2-carboxyethyl)-5(6)-carboxyfluorescein are used to measure changes in intracellular pH (pHi) and processes such as dendrimer aggregation and absorption.
Related Catalog
References

[1]. Babcock DF. Examination of the intracellular ionic environment and of ionophore action by null point measurements employing the fluorescein chromophore. J Biol Chem. 1983 May 25;258(10):6380-9.

[2]. Graber ML, et al. Characteristics of fluoroprobes for measuring intracellular pH. Anal Biochem. 1986 Jul;156(1):202-12.

[3]. Bonizzoni M, et al. PAMAM dendrimer-induced aggregation of 5(6)-carboxyfluorescein. J Org Chem. 2012 Feb 3;77(3):1258-66.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 701.6±60.0 °C at 760 mmHg
Melting Point 152–153°C
Molecular Formula C25H16O9
Molecular Weight 460.389
Flash Point 245.1±26.4 °C
Exact Mass 460.079437
PSA 125.43000
LogP 2.45
Appearance of Characters Light yellow or off-white solid
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.702
Storage condition 2-8°C
Water Solubility DMSO: soluble

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2932999099

 Synthetic Route

Ethanoic anhydride structure

Ethanoic anhydride

CAS#:108-24-7

2-(3-hydroxy-6-oxoxanthen-9-yl)terephthalic acid structure

2-(3-hydroxy-6-...

CAS#:76608-15-6

~%

6-Carboxyfluorescein Diacetate Structure

6-Carboxyfluore...

CAS#:3348-03-6

Literature: US2013/65263 A1, ; Paragraph 0083; 0084 ;

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

6-FAM DA
6-CFDA 6-Carboxy-di-O-acetylfluorescein
6-CFDA
MFCD00036871
6-Carboxyfluorescein diacetate
3',6'-Diacetoxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-6-carboxylic acid
6-Carboxy-di-O-acetylfluorescein,6-CFDA
5,6-diacetyl FAM-SE
6-CARBOXY-DI-O-ACETYLFLUORESCEIN
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid, 3',6'-bis(acetyloxy)-3-oxo-
3',6'-Diacetoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-carboxylic acid
6-FAM DIACETATE
6-Carboxyfluorescein diacetate,6-CFDA,6-Carboxy-di-O-acetylfluorescein
6-CARBOXYFLUORESCEINE DIACETATE
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