Nalidixic acid sodium salt
Modify Date: 2024-01-02 17:15:59
Nalidixic acid sodium salt structure
|
Common Name | Nalidixic acid sodium salt | ||
|---|---|---|---|---|
| CAS Number | 3374-05-8 | Molecular Weight | 254.21700 | |
| Density | 1.331g/cm3 | Boiling Point | 413.1ºC at 760mmHg | |
| Molecular Formula | C12H11N2NaO3 | Melting Point | 229-230ºC | |
| MSDS | Chinese USA | Flash Point | 203.6ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
Use of Nalidixic acid sodium saltNalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1][2]. |
| Name | Nalidixic acid sodium salt |
|---|---|
| Synonym | More Synonyms |
| Description | Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Topoisomerase |
| In Vitro | Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli, Pasteurella spp., Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp., Salmonella spp., Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively[1]. |
| In Vivo | The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused by E. coli, A. aerobacter, Proteus mirabilis, Shigella fkxneri, the ED50 values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively[1]. The acute toxicity (LD50) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg; and subcutaneous, 500 mg/kg[1]. |
| References |
[2]. Anna Fàbrega, et al. Mechanism of Action of and Resistance to Quinolones. Microb Biotechnol |
| Density | 1.331g/cm3 |
|---|---|
| Boiling Point | 413.1ºC at 760mmHg |
| Melting Point | 229-230ºC |
| Molecular Formula | C12H11N2NaO3 |
| Molecular Weight | 254.21700 |
| Flash Point | 203.6ºC |
| Exact Mass | 254.06700 |
| PSA | 75.02000 |
| LogP | 0.08830 |
| Storage condition | 2-8°C |
| Water Solubility | H2O: 50 mg/mL, clear, faintly yellow |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H317-H334 |
| Precautionary Statements | P261-P280-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R42/43 |
| Safety Phrases | S22-S36/37-S45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | - |
| RTECS | QN2885500 |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Differential regulation of OmpC and OmpF by AtpB in Escherichia coli exposed to nalidixic acid and chlortetracycline.
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| nalidixic acid sodium |
| sodiumnalidixate |
| EINECS 222-159-7 |
| MFCD00064376 |
| sodium nalidixicate |
| sodiumnilixalate |
| nalidixic acid sodium salt |
| nalidixic acid,sodium salt |
| nalidixatesodium |
| sodium 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate |
| NALIDIXIC ACID SODIUM SALT MOLECULAR BIOLOGY REAGENT |
| 8-naphthyridine-3-carboxylicacid,1-ethyl-1,4-dihydro-7-methyl-4-oxo-sodiu |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Nalidixic acid sodium salt
- Price: ￥168.0/1g ￥498.0/5g ￥5378.0/100g ￥1748.0/25g
- Purity: 98.0%
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- DC Chemicals Limited
- China
- Product Name: Nalidixic acid sodium salt
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Cao
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Nalidixic acid sodium salt
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
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