3-MORPHOLINOSYDNONIMINE
Modify Date: 2025-08-27 09:14:35
3-MORPHOLINOSYDNONIMINE structure
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Common Name | 3-MORPHOLINOSYDNONIMINE | ||
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| CAS Number | 33876-97-0 | Molecular Weight | 170.16900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C6H10N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 3-MORPHOLINOSYDNONIMINE3-Morpholinosydnonimine (SIN-1; Linsidomine) is a spontaneous ROS/RNS generator and a peroxynitrite donor. 3-Morpholinosydnonimine inhibits hypertrophic chondrocytes activity and induces necrosis. 3-Morpholinosydnonimine induces p53-dependent apoptosis, induces p53 accumulation and activates MAPK phosphorylation[1][2]. |
| Name | 3-morpholin-4-yl-1-oxa-3-azonia-2-azanidacyclopent-3-en-5-imine |
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| Synonym | More Synonyms |
| Description | 3-Morpholinosydnonimine (SIN-1; Linsidomine) is a spontaneous ROS/RNS generator and a peroxynitrite donor. 3-Morpholinosydnonimine inhibits hypertrophic chondrocytes activity and induces necrosis. 3-Morpholinosydnonimine induces p53-dependent apoptosis, induces p53 accumulation and activates MAPK phosphorylation[1][2]. |
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| Related Catalog | |
| In Vitro | 3-Morpholinosydnonimine (1,3,5 mM; 24 h) 抑制肥厚性软骨细胞活力[1]。 3-Morpholinosydnonimine (3 mM 和 5 mM; 24 h) 诱导肥大软骨细胞坏死死亡，同时诱导 ATDC5 细胞和 C28/I2 细胞凋亡死亡[1]。 3-Morpholinosydnonimine (50 μM, 200 μM, 400 μM; 6 h) 在富含神经元的小鼠端脑细胞中诱导 p53 的表达迅速增加，并诱导 p53 依赖的凋亡[2]。 3-Morpholinosydnonimine (200 μM; 6 h) 通过 p21(ras) 激活诱导 p53 积累[2]。 Cell Viability Assay[1] Cell Line: Hypertrophic chondrocytes Concentration: 0 mM, 1 mM, 3 mM, and 5 mM Incubation Time: 0 h, 4 h, 8 h, 12 h, and 24 h Result: Decreased the cellular viability by 30%, 50%, and 80% respectively at 1, 3, and 5 mM. Western Blot Analysis[2] Cell Line: Mouse primary neural cells Concentration: 200 μM Incubation Time: 6 h Result: Induced p53 accumulation. |
| References |
| Molecular Formula | C6H10N4O2 |
|---|---|
| Molecular Weight | 170.16900 |
| Exact Mass | 170.08000 |
| PSA | 67.28000 |
| InChIKey | FKDHHVKWGRFRTG-UHFFFAOYSA-N |
| SMILES | N=c1c[n+](N2CCOCC2)[n-]o1 |
| WGK Germany | 3 |
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3-MORPHOLINOSYD... CAS#:33876-97-0 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 18, p. 128 - 132 |
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3-MORPHOLINOSYD... CAS#:33876-97-0 |
| Literature: Journal of Heterocyclic Chemistry, , vol. 7, p. 123 - 129 |
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| 3-morpholinosydnoimine |
| Linsidomine |
| 3-morpholinosydnonimine-N-ethylcarbamide |
| 3-Morpholinosydnonimine-1 |
| 3-morpholino sydnonimine |
| sin-1 |
| CV 664 |
| 3-Morpholinosydnoneimine |