Silicristin

Modify Date: 2024-01-02 20:13:29

Silicristin structure	Common Name	Silicristin
	CAS Number	33889-69-9	Molecular Weight	482.436
	Density	1.6±0.1 g/cm3	Boiling Point	782.0±60.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₂₂O₁₀	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	270.5±26.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of Silicristin

Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2].

Name	silychristin
Synonym	More Synonyms

Description	Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Others
References	[1]. Biedermann D, et al. Silychristin: Skeletal Alterations and Biological Activities. J Nat Prod. 2016 Dec 23;79(12):3086-3092. [2]. Johannes J, et al. Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. Endocrinology. 2016 Apr;157(4):1694-701.

Description

Related Catalog

Research Areas >> Endocrinology

Signaling Pathways >> Others >> Others

References

[1]. Biedermann D, et al. Silychristin: Skeletal Alterations and Biological Activities. J Nat Prod. 2016 Dec 23;79(12):3086-3092.

[2]. Johannes J, et al. Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. Endocrinology. 2016 Apr;157(4):1694-701.

Density	1.6±0.1 g/cm3
Boiling Point	782.0±60.0 °C at 760 mmHg
Molecular Formula	C₂₅H₂₂O₁₀
Molecular Weight	482.436
Flash Point	270.5±26.4 °C
Exact Mass	482.121307
PSA	166.14000
LogP	2.20
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.716
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	22-45
RIDADR	NONH for all modes of transport

Precursor 3
CAS#:1835-11-6 1-(4-(Benzyloxy... CAS#:124662-51-7 1-(4-benzyloxy-... CAS#:16414-34-9 Benzaldehyde,3-...
DownStream 0

Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes.

Pharmacol. Res. 25(2) , 147-54, (1992)

The effect of several flavanolignans (silicristin, silidianin, silybin and isosilybin) present in silymarin, the extract of Silybum marianum fruits, was tested on lipid peroxidation in rat liver micro...

Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.

J. Chromatogr. A. 1116(1-2) , 57-68, (2006)

A selective and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed for the characterization of silymarin in commercially available milk thistle extract. In t...

Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.

Int. J. Cancer 123(1) , 41-50, (2008)

Prostate cancer (PCa) is the leading cause of cancer-related deaths in men; urgent measures are warranted to lower this deadly malignancy. Silymarin is a known cancer chemopreventive agent, but the re...

Silicristin

EINECS 251-720-9

Silicristinum

(2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydrochromen-4-one

Silicristinum [INN-Latin]

Silicristina

(2R,3R)-3,5,7-Trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydro-4H-chromen-4-one

Silicristina [INN-Spanish]

4H-1-Benzopyran-4-one, 2-[(2R,3S)-2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-

Silychristin

Silymarin II

Silicristine [INN-French]

(2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-2,3-dihydrobenzofuran-5-yl]chroman-4-one

Silicristine