Angiotensin I/II (5-8)

Modify Date: 2025-08-25 08:33:13

Angiotensin I/II (5-8) structure	Common Name	Angiotensin I/II (5-8)
	CAS Number	34233-50-6	Molecular Weight	512.60
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₃₆N₆O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Angiotensin I/II (5-8)

Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II[1]. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney[2][3].

Name	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
Synonym	More Synonyms

Description	Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II[1]. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney[2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Metabolic Disease
References	[1]. Guethe LM, et al. Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid. Neuroscience. 2013 Feb 12;231:315-27. [2]. De Giusti VC, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411. [3]. Moon JY, et al. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-5.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor

Research Areas >> Metabolic Disease

References

[1]. Guethe LM, et al. Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid. Neuroscience. 2013 Feb 12;231:315-27.

[2]. De Giusti VC, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411.

[3]. Moon JY, et al. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-5.

Molecular Formula	C₂₆H₃₆N₆O₅
Molecular Weight	512.60
Exact Mass	512.27500
PSA	177.49000
LogP	2.93230

IHPF

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Angiotensin I/II (5-8)

Use of Angiotensin I/II (5-8)

Names

Angiotensin I/II (5-8) Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.