EMI48

Modify Date: 2025-08-26 17:36:41

EMI48 Structure
EMI48 structure
Common Name EMI48
CAS Number 34564-13-1 Molecular Weight 348.39500
Density N/A Boiling Point N/A
Molecular Formula C21H20N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of EMI48


EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants[1].

 Names

Name 7-(diethylamino)-3-(5-methyl-1,3-benzoxazol-2-yl)chromen-2-one
Synonym More Synonyms

 EMI48 Biological Activity

Description EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants[1].
Related Catalog
Target

EGFRL858R/T790M/C797S

EGFRdel19 T790M C797S

In Vitro EMI48 inhibits EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S. EMI48 can be used in the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1].
References

[1]. Punit Saraon , et al. A Drug Discovery Platform to Identify Compounds That Inhibit EGFR Triple Mutants.Nat Chem Biol. 2020 May;16(5):577-586.

 Chemical & Physical Properties

Molecular Formula C21H20N2O3
Molecular Weight 348.39500
Exact Mass 348.14700
PSA 59.48000
LogP 4.75580

 Synonyms

EINECS 252-093-4
disperse yellow 184
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