Diethyl malonate

Modify Date: 2024-01-01 19:07:35

Diethyl malonate Structure
Diethyl malonate structure
 Common Name Diethyl malonate
CAS Number 105-53-3 Molecular Weight 160.168
Density 1.1±0.1 g/cm3 Boiling Point 199.3±0.0 °C at 760 mmHg
Molecular Formula C7H12O4 Melting Point -50 °C
MSDS Chinese USA Flash Point 100.0±0.0 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Names

Name Diethyl malonate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 199.3±0.0 °C at 760 mmHg
Melting Point -50 °C
Molecular Formula C7H12O4
Molecular Weight 160.168
Flash Point 100.0±0.0 °C
Exact Mass 160.073563
PSA 52.60000
LogP 0.70
Vapour density 5.52 (vs air)
Vapour Pressure 0.3±0.3 mmHg at 25°C
Index of Refraction 1.418
Stability Stable. Combustible. Incompatible with strong oxidizing agents,

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OO0700000
CHEMICAL NAME :
Malonic acid, diethyl ester
CAS REGISTRY NUMBER :
105-53-3
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C7-H12-O4
MOLECULAR WEIGHT :
160.19
WISWESSER LINE NOTATION :
2OV1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,745,1976 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14900 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6400 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year: 34,1196,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>16 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4574 No. of Facilities: 312 (estimated) No. of Industries: 7 No. of Occupations: 9 No. of Employees: 6753 (estimated) No. of Female Employees: 1766 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S24/25
WGK Germany 1
RTECS OO0700000
HS Code 2917190090

 Synthetic Route

 Customs

HS Code 2917190090
Summary 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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 Synonyms

UNII-53A58PA183
diethyl propanedioate
Propanedioic acid, diethyl ester
MFCD00009195
Diethyl Malonate
Ethyl Malonate
Malonic acid diethyl ester
EINECS 203-305-9
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