5-Methylurapidil

Modify Date: 2024-01-04 04:22:48

5-Methylurapidil Structure
5-Methylurapidil structure
Common Name 5-Methylurapidil
CAS Number 34661-85-3 Molecular Weight 437.96300
Density N/A Boiling Point N/A
Molecular Formula C21H32ClN5O3 Melting Point N/A
MSDS USA Flash Point N/A

 Use of 5-Methylurapidil


5-Methylurapidil isα1A‐adrenoceptor antagonist. 5-Methylurapidil can be used for the research of cardiovascular diseases such as hypertension and heart failure[1].

 Names

Name 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3,5-trimethylpyrimidine-2,4-dione,hydrochloride
Synonym More Synonyms

 5-Methylurapidil Biological Activity

Description 5-Methylurapidil isα1A‐adrenoceptor antagonist. 5-Methylurapidil can be used for the research of cardiovascular diseases such as hypertension and heart failure[1].
Related Catalog
References

[1]. Arce C, et al. Activation of α1A -adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing. Br J Pharmacol. 2017 Jul;174(13):2015-2030.  

 Chemical & Physical Properties

Molecular Formula C21H32ClN5O3
Molecular Weight 437.96300
Exact Mass 437.21900
PSA 71.74000
LogP 1.90310

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles30

More Articles
Cell membrane chromatography competitive binding analysis for characterization of α1A adrenoreceptor binding interactions.

Anal. Bioanal. Chem 400(10) , 3625-33, (2011)

A new high α(1A) adrenoreceptor (α(1A)AR) expression cell membrane chromatography (CMC) method was developed for characterization of α(1A)AR binding interactions. HEK293 α(1A) cell line, which express...

Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats.

Auton. Autacoid Pharmacol. 29(1-2) , 25-31, (2009)

1 Increased renal vascular resistance is one renal functional abnormality that contributes to hypertension, and alpha(1)-adrenoceptors play a pivotal role in modulating this renal vascular resistance....

Alpha-1A adrenergic receptor activation increases inhibitory tone in CA1 hippocampus.

Epilepsy Res. 84(2-3) , 97-109, (2009)

The endogenous catecholamine norepinephrine (NE) exhibits anti-epileptic properties, however it is not well understood which adrenergic receptor (AR) mediates this effect. The aim of this study was to...

 Synonyms

5-Methyl-6[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil