2,2,2-trifluoro-N-(4-phenylphenyl)acetamide

Modify Date: 2025-08-27 12:25:24

2,2,2-trifluoro-N-(4-phenylphenyl)acetamide Structure
2,2,2-trifluoro-N-(4-phenylphenyl)acetamide structure
Common Name 2,2,2-trifluoro-N-(4-phenylphenyl)acetamide
CAS Number 347-37-5 Molecular Weight 265.23100
Density 1.298g/cm3 Boiling Point 370.8ºC at 760 mmHg
Molecular Formula C14H10F3NO Melting Point N/A
MSDS N/A Flash Point 178.1ºC

 Names

Name N-([1,1'-biphenyl]-4-yl)-2,2,2-trifluoroacetamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.298g/cm3
Boiling Point 370.8ºC at 760 mmHg
Molecular Formula C14H10F3NO
Molecular Weight 265.23100
Flash Point 178.1ºC
Exact Mass 265.07100
PSA 29.10000
LogP 3.92740
Index of Refraction 1.555
InChIKey UEZRDXDUQAKINL-UHFFFAOYSA-N
SMILES O=C(Nc1ccc(-c2ccccc2)cc1)C(F)(F)F

 Synthetic Route

~65%

2,2,2-trifluoro-N-(4-phenylphenyl)acetamide Structure

2,2,2-trifluoro...

CAS#:347-37-5

Literature: BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KLEY, Joerg; HAMILTON, Bradford, S.; MACK, Juergen; REDEMANN, Norbert; SCHOELCH, Corinna Patent: WO2011/48018 A1, 2011 ; Location in patent: Page/Page column 38 ; WO 2011/048018 A1

~99%

2,2,2-trifluoro-N-(4-phenylphenyl)acetamide Structure

2,2,2-trifluoro...

CAS#:347-37-5

Literature: Tao, Chuan-Zhou; Li, Juan; Fu, Yao; Liu, Lei; Guo, Qing-Xiang Tetrahedron Letters, 2008 , vol. 49, # 1 p. 70 - 75

~94%

2,2,2-trifluoro-N-(4-phenylphenyl)acetamide Structure

2,2,2-trifluoro...

CAS#:347-37-5

Literature: Wright, Stephen W.; Hageman, David L.; McClure, Lester D. Journal of Organic Chemistry, 1994 , vol. 59, # 20 p. 6095 - 6097

~93%

2,2,2-trifluoro-N-(4-phenylphenyl)acetamide Structure

2,2,2-trifluoro...

CAS#:347-37-5

Literature: Han, Ki-Jong; Kim, Misoo Letters in Organic Chemistry, 2011 , vol. 8, # 8 p. 559 - 561

~%

2,2,2-trifluoro-N-(4-phenylphenyl)acetamide Structure

2,2,2-trifluoro...

CAS#:347-37-5

Literature: Wright, Stephen W.; Hageman, David L.; McClure, Lester D. Journal of Organic Chemistry, 1994 , vol. 59, # 20 p. 6095 - 6097

~7%

Detail
Literature: Takeuchi, Hiroshi; Taniguchi, Tomohito; Ueda, Takahiro Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 2 p. 295 - 300

~%

2,2,2-trifluoro-N-(4-phenylphenyl)acetamide Structure

2,2,2-trifluoro...

CAS#:347-37-5

Literature: Takeuchi, Hiroshi; Taniguchi, Tomohito; Ueda, Takahiro Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 2 p. 295 - 300

~%

2,2,2-trifluoro-N-(4-phenylphenyl)acetamide Structure

2,2,2-trifluoro...

CAS#:347-37-5

Literature: Takeuchi, Hiroshi; Taniguchi, Tomohito; Ueda, Takahiro Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 2 p. 295 - 300

~11%

Detail
Literature: Takeuchi, Hiroshi; Taniguchi, Tomohito; Ueda, Takahiro Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 2 p. 295 - 300

 Bioassay

View more

Name: NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L...
Source: DTP/NCI
Target: N/A
External Id: MCF7_OneDose
Name: NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell...
Source: DTP/NCI
Target: N/A
External Id: IGROV1_OneDose
Name: Cell-based high throughput primary assay to identify activators of GPR151
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL
External Id: GPR151_PHUNTER_AG_LUMI_1536_1X%ACT
Name: AlphaScreen-based biochemical high throughput primary assay to identify activators of...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: FBW7_ACT_ALPHA_1536_1X%ACT PRUN
Name: AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of...
Source: The Scripps Research Institute Molecular Screening Center
External Id: MITF_INH_Alpha_1536_1X%INH PRUN
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 Synonyms

4-Trifluoroacetylaminobiphenyl
1H-Pyrrole-2,5-dione,1-(4-phenylbutyl)
1-(4-phenybutyl)maleimide
1-(4-Phenylbutyl)Maleimide
N-4-Diphenyl-trifluoracetamid
N-(biphenyl-4-yl)-2,2,2-trifluoro-acetamide
N-(4-Phenyl-n-butyl)-maleinsaeureimid
Trifluor-essigsaeure-biphenyl-4-ylamid
trifluoro-acetic acid biphenyl-4-ylamide
N-(4-phenylphenyl)trifluoroacetamide
2,2,2-trifluoro-4'-phenylacetanilide
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