LTV-1
Modify Date: 2024-01-04 02:42:01
LTV-1 structure
|
Common Name | LTV-1 | ||
|---|---|---|---|---|
| CAS Number | 347379-29-7 | Molecular Weight | 472.512 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C26H20N2O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LTV-1LTV-1 is a highly potent, cell-permeable and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50 = 508 nM). IC50 value: 508 nMTarget: LYPin vitro: LTV-1 inhibits LYP in a dose-dependent manner at low- and sub-micromolar concentrations in T cells. LTV-1 enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki = 384 nM). LTV-1 inhibits the mutant, disease associated LYP-Trp620 activity. LTV-1 blocks the action of the mutant LYP protein in human T cells. |
| Name | LTV-1 |
|---|---|
| Synonym | More Synonyms |
| Description | LTV-1 is a highly potent, cell-permeable and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50 = 508 nM). IC50 value: 508 nMTarget: LYPin vitro: LTV-1 inhibits LYP in a dose-dependent manner at low- and sub-micromolar concentrations in T cells. LTV-1 enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki = 384 nM). LTV-1 inhibits the mutant, disease associated LYP-Trp620 activity. LTV-1 blocks the action of the mutant LYP protein in human T cells. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C26H20N2O5S |
| Molecular Weight | 472.512 |
| Exact Mass | 472.109283 |
| LogP | 4.99 |
| Index of Refraction | 1.723 |
| Storage condition | 2-8℃ |
| Benzoic acid, 3-[[4-[(E)-[tetrahydro-1-(2-methylphenyl)-4,6-dioxo-2-thioxo-5(2H)-pyrimidinylidene]methyl]phenoxy]methyl]- |
| 3-[(4-{(E)-[1-(2-Methylphenyl)-4,6-dioxo-2-thioxotetrahydro-5(2H)-pyrimidinylidene]methyl}phenoxy)methyl]benzoic acid |
| benzoic acid, 3-[[4-[(E)-[1,6-dihydro-2-mercapto-1-(2-methylphenyl)-4,6-dioxo-5(4H)-pyrimidinylidene]methyl]phenoxy]methyl]- |
| 3-[(4-{(E)-[1-(2-methylphenyl)-4,6-dioxo-2-thioxotetrahydropyrimidin-5(2H)-ylidene]methyl}phenoxy)methyl]benzoic acid |