Ticarcillin

Modify Date: 2024-01-02 17:13:47

Ticarcillin structure	Common Name	Ticarcillin
	CAS Number	34787-01-4	Molecular Weight	384.427
	Density	1.6±0.1 g/cm3	Boiling Point	768.3±60.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₆N₂O₆S₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	418.4±32.9 °C
	Symbol	GHS08	Signal Word	Danger

Use of Ticarcillin

Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research[1][2][3].

Name	ticarcillin
Synonym	More Synonyms

Description	Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Ticarcillin treatment (10 mg/L; 18 h) shows antibacterial activities[1]. Cell Viability Assay[2] Cell Line: Ps. aeruginosa Concentration: 10 mg/L Incubation Time: 18 hours Result: Showed the MIC for Ticarcillin against strain between 6.3-12.5 mg/L.
In Vivo	Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows a dose-dependent antibacterial effect[2]. Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows excellent pharmacokinetic assessment[2]. Animal Model: Swiss type male mice injected with Ps. aeruginosa[2] Dosage: 50, 100, 200 mg/kg Administration: Subcutaneous injection; 50, 100, 200 mg/kg; once Result: Increased effect significantly (0.001 < P < 0.0025) with increasing dose. Animal Model: Swiss type male mice injected with Ps. aeruginosa[2] Dosage: 50, 100, 200 mg/kg Administration: Subcutaneous injection; 50, 100, 200 mg/kg; once Result: Dose (mg/kg) AUCa (mg/kg) Kelb (h-1) T1/2 (min) Ticarcillin 50 8.76 (0.72) 1.57 (0.18) 26 100 26.14 (0.60) 1.53 (0.11) 27 200 54.56 (2.90) 1.47 (0.12) 28
References	[1]. Cecile Formosa, et al. Nanoscale effects of antibiotics on P. aeruginosa. Nanomedicine. 2012 Jan;8(1):12-6. [2]. G B van der Voet, et al. Comparison of the antibacterial activity of azlocillin and ticarcillin in vitro and in irradiated neutropenic mice. J Antimicrob Chemother. 1985 Nov;16(5):605-13. [3]. Oriel Spierer, et al. Comparative activity of antimicrobials against Pseudomonas aeruginosa, Achromobacter xylosoxidans and Stenotrophomonas maltophilia keratitis isolates. Br J Ophthalmol. 2018 May;102(5):708-712.

Density	1.6±0.1 g/cm3
Boiling Point	768.3±60.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₆N₂O₆S₂
Molecular Weight	384.427
Flash Point	418.4±32.9 °C
Exact Mass	384.044983
PSA	177.55000
LogP	0.69
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.694
Storage condition	2-8°C

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H317-H334
Precautionary Statements	P261-P280-P342 + P311
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R42/43
Safety Phrases	22-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	3

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(2S,5R,6R)-6-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Temocillin Disodium

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[(carboxy-3-thienylacetyl)amino]-3,3-dimethyl-7-oxo-,[2S-[2a,5a,6b(S*)]]

6-[D(-)-a-Carboxy-3-thienylacetamido]penicillanic Acid

EINECS 252-213-5

(2S,5R,6R)-6-{[(2R)-2-Carboxy-2-(3-thienyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Ticarcillin

(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-yl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

6-[D-(-)-a-Carboxy-3-thienylacetamido]penicillanic acid

a-Carboxy-3-thienylmethylpenicillin

N-(2-Carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-3-thiophenemalonamic Acid

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-carboxy-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-

TRIARCILLIN

MFCD00864998

Ticcarcillin acid

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ticarcillin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Potassium clavulanate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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