2-Amino-6-fluorobenzothiazole

Modify Date: 2025-08-23 17:31:46

2-Amino-6-fluorobenzothiazole Structure
2-Amino-6-fluorobenzothiazole structure
Common Name 2-Amino-6-fluorobenzothiazole
CAS Number 348-40-3 Molecular Weight 168.191
Density 1.5±0.1 g/cm3 Boiling Point 312.0±34.0 °C at 760 mmHg
Molecular Formula C7H5FN2S Melting Point 183-185 °C(lit.)
MSDS Chinese USA Flash Point 142.5±25.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 6-fluoro-1,3-benzothiazol-2-amine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 312.0±34.0 °C at 760 mmHg
Melting Point 183-185 °C(lit.)
Molecular Formula C7H5FN2S
Molecular Weight 168.191
Flash Point 142.5±25.7 °C
Exact Mass 168.015747
PSA 67.15000
LogP 1.94
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.726
InChIKey CJLUXPZQUXVJNF-UHFFFAOYSA-N
SMILES Nc1nc2ccc(F)cc2s1

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22;R36/37/38
Safety Phrases S26-S37/39-S36/37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090

 Synthetic Route

~88%

2-Amino-6-fluorobenzothiazole Structure

2-Amino-6-fluor...

CAS#:348-40-3

Literature: Thaker; Chothani; Patel; Dhimmar; Solanki; Patel, Neeraj; Makawana Molecular Crystals and Liquid Crystals, 2013 , vol. 575, # 1 p. 64 - 76

~82%

2-Amino-6-fluorobenzothiazole Structure

2-Amino-6-fluor...

CAS#:348-40-3

Literature: Charris, Jaime; Monasterios, Melina; Dominguez, Josee; Infante, Wilson; Castro, Norma De Heterocyclic Communications, 2002 , vol. 8, # 3 p. 275 - 280

~42%

2-Amino-6-fluorobenzothiazole Structure

2-Amino-6-fluor...

CAS#:348-40-3

Literature: Jacquot, Yves; Cleeren, Anny; Laios, Ioanna; Ma, Yan; Boulahdour, Athem; Bermont, Laurent; Refouvelet, Bernard; Adessi, Gerard; Leclercq, Guy; Xicluna, Alain Biological and Pharmaceutical Bulletin, 2002 , vol. 25, # 3 p. 335 - 341

~%

2-Amino-6-fluorobenzothiazole Structure

2-Amino-6-fluor...

CAS#:348-40-3

Literature: US2061186 , ;

~%

2-Amino-6-fluorobenzothiazole Structure

2-Amino-6-fluor...

CAS#:348-40-3

Literature: Bioorganic and Medicinal Chemistry, , vol. 14, # 16 p. 5678 - 5682

~%

2-Amino-6-fluorobenzothiazole Structure

2-Amino-6-fluor...

CAS#:348-40-3

Literature: Die Pharmazie, , vol. 22, # 6 p. 229 - 233

~%

2-Amino-6-fluorobenzothiazole Structure

2-Amino-6-fluor...

CAS#:348-40-3

Literature: Journal of the Indian Chemical Society, , vol. 8, p. 147,163

~%

2-Amino-6-fluorobenzothiazole Structure

2-Amino-6-fluor...

CAS#:348-40-3

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 27, # 1-12 p. 189 - 190

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 2-Amino-6-fluorobenzothiazoleBioassay

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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
Name: Tested for the protection against glutamic acid-evoked convulsions in rats by intrape...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL783725
Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity
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 Synonyms

6-Fluoro-1,3-benzothiazol-2-amine
2-amino-6-fluorobenzthiazole
6-Fluorobenzo[d]thiazol-2-amine
MFCD00013336
2-Amino-6-fluorobenzothiazole
2-amino-6-fluoro-1,3-benzothiazole
6-fluoro-2-amino-1,3-benzothiazole
6-fluorobenzothiazole-2-ylamine
2-amino-6-fluoro-benzothiazole
6-fluoro-benzothiazol-2-ylamine
6-fluoro-2-benzothiazolamine
2-Benzothiazolamine,6-fluoro
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