Tomaymycin

Modify Date: 2024-01-09 23:50:07

Tomaymycin structure	Common Name	Tomaymycin
	CAS Number	35050-55-6	Molecular Weight	304.34100
	Density	1.32g/cm3	Boiling Point	541.2ºC at 760 mmHg
	Molecular Formula	C₁₆H₂₀N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	281.1ºC

Use of Tomaymycin

Tomaymycin is an antitumor antibiotic. Tomaymycin has antimicrobial activity against Grampositive bacteria[1][2].

Name	5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one,2-ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy-7,11-dimethoxy-,(2E,11R,11aS)

Description	Tomaymycin is an antitumor antibiotic. Tomaymycin has antimicrobial activity against Grampositive bacteria[1][2].
Related Catalog	Research Areas >> Infection
Target	Antibiotic[1][2]
In Vivo	Tomaymycin, an antiphage antibiotic is produced by cultivation of Streptomyces achromogenes var. tomaymyceticus in a lactose-bouillon medium enriched with yeast extract and phosphate salts. The antiphage activity is strong against Escherichia coli T1, T3 phages and Bacillus subtilis M-2, SP-10 phages. The LD50 (i.p.) of tomaymycin for mice is estimated at 3.0 mg/kg.
References	[1]. F L Boyd, et al. Characterization of a unique tomaymycin-d(CICGAATTCICG)2 adduct containing two drug molecules per duplex by NMR, fluorescence, and molecular modeling studies. Biochemistry. 1990 Mar 6;29(9):2387-403. [2]. K Arima, et al. Studies on tomaymycin, a new antibiotic. I. Isolation and properties of tomaymycin. J Antibiot (Tokyo). 1972 Aug;25(8):437-44.

Density	1.32g/cm3
Boiling Point	541.2ºC at 760 mmHg
Molecular Formula	C₁₆H₂₀N₂O₄
Molecular Weight	304.34100
Flash Point	281.1ºC
Exact Mass	304.14200
PSA	71.03000
LogP	2.03550
Index of Refraction	1.622

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY8533000

CHEMICAL NAME :: 5H-Pyrrolo(2,1-c)(1,4)benzodiazepin-5-one, 2-ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy- 7,11-dimethoxy-, (11R-(2E,11-alpha,11a-beta))-

CAS REGISTRY NUMBER :: 35050-55-6

LAST UPDATED :: 199509

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H20-N2-O4

MOLECULAR WEIGHT :: 304.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3540 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Phage inhibition capacity

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 100 ng/plate

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,2819,1983

DC Chemicals Limited
China
Product Name: Tomaymycin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one,2-ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy-7,11-dimethoxy-,(2E,11R,11aS)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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