Vacuolin-1
Modify Date: 2024-02-05 18:31:30
Vacuolin-1 structure
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Common Name | Vacuolin-1 | ||
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| CAS Number | 351986-85-1 | Molecular Weight | 577.419 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 719.7±70.0 °C at 760 mmHg | |
| Molecular Formula | C26H24IN7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 389.1±35.7 °C | |
Use of Vacuolin-1A potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A; blocks the Ca(2+)-dependent exocytosis of lysosomes induced by ionomycin or plasma membrane wounding, without affecting the process of resealing, induces the formation of giant vacuoles. |
| Name | 4-[(2E)-2-(3-Iodobenzylidene)hydrazino]-6-(4-morpholinyl)-N,N-diphenyl-1,3,5-triazin-2-amine |
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| Synonym | More Synonyms |
| Description | A potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A; blocks the Ca(2+)-dependent exocytosis of lysosomes induced by ionomycin or plasma membrane wounding, without affecting the process of resealing, induces the formation of giant vacuoles. |
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| References | References 1. Cerny J, et al. EMBO Rep. 2004 Sep;5(9):883-8. 2. Shaik GM, et al. Cell Signal. 2009 Aug;21(8):1337-45. 3. Lu Y, et al. Autophagy. 2014;10(11):1895-905. 4. Sano O, et al. FEBS Lett. 2016 Jun;590(11):1576-85. View Related Products by Target Autophagy |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 719.7±70.0 °C at 760 mmHg |
| Molecular Formula | C26H24IN7O |
| Molecular Weight | 577.419 |
| Flash Point | 389.1±35.7 °C |
| Exact Mass | 577.108704 |
| LogP | 4.41 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.706 |
| Hazard Codes | Xi |
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| 4-[(2E)-2-(3-Iodobenzylidene)hydrazino]-6-(morpholin-4-yl)-N,N-diphenyl-1,3,5-triazin-2-amine |
| 4-[(2E)-2-(3-Iodobenzylidene)hydrazino]-6-(4-morpholinyl)-N,N-diphenyl-1,3,5-triazin-2-amine |
| Benzaldehyde, 3-iodo-, 2-[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone |