(2S)-2-Amino(3,3-2H2)butanoic acid

Modify Date: 2024-05-02 22:32:47

(2S)-2-Amino(3,3-2H2)butanoic acid Structure
(2S)-2-Amino(3,3-2H2)butanoic acid structure
Common Name (2S)-2-Amino(3,3-2H2)butanoic acid
CAS Number 352431-37-9 Molecular Weight 105.13
Density 1.1±0.1 g/cm3 Boiling Point 215.2±23.0 °C at 760 mmHg
Molecular Formula C4H7D2NO2 Melting Point N/A
MSDS N/A Flash Point 83.9±22.6 °C

 Use of (2S)-2-Amino(3,3-2H2)butanoic acid


H-Abu-OH-d2 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.

 Names

Name l-2-aminobutyric-3,3-d2 acid
Synonym More Synonyms

 (2S)-2-Amino(3,3-2H2)butanoic acid Biological Activity

Description H-Abu-OH-d2 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Yudkoff M, et al. On the clinical significance of the plasma alpha-amino-n-butyric acid:leucine ratio. Am J Clin Nutr. 1979 Feb;32(2):282-5.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 215.2±23.0 °C at 760 mmHg
Molecular Formula C4H7D2NO2
Molecular Weight 105.13
Flash Point 83.9±22.6 °C
Exact Mass 105.075882
PSA 63.32000
LogP -0.15
Vapour Pressure 0.1±0.9 mmHg at 25°C
Index of Refraction 1.462

 Synonyms

(2S)-2-Amino(3,3-H)butanoic acid
Butanoic-3,3-d acid, 2-amino-, (2S)-