352431-37-9

352431-37-9 structure

Name: (2S)-2-Amino(3,3-2H2)butanoic acid
Chemical Name: l-2-aminobutyric-3,3-d2 acid
CAS Number: 352431-37-9
Molecular Formula: C₄H₇D₂NO₂
Molecular Weight: 105.13
Create Date: 2018-02-12 08:00:00
Modify Date: 2024-05-02 22:32:47
H-Abu-OH-d2 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.

Name	l-2-aminobutyric-3,3-d2 acid
Synonyms	(2S)-2-Amino(3,3-H)butanoic acid Butanoic-3,3-d acid, 2-amino-, (2S)-

Description	H-Abu-OH-d2 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Yudkoff M, et al. On the clinical significance of the plasma alpha-amino-n-butyric acid:leucine ratio. Am J Clin Nutr. 1979 Feb;32(2):282-5.