PJ-68
Modify Date: 2024-01-11 17:39:09
PJ-68 structure
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Common Name | PJ-68 | ||
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| CAS Number | 352544-59-3 | Molecular Weight | 354.487 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 553.4±42.0 °C at 760 mmHg | |
| Molecular Formula | C25H26N2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 288.5±27.9 °C | |
Use of PJ-68PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8); markedly decreases BCR-ABL mRNA levels in both CD34+CD38-cells and CD34+CD38+ cells, reduces survival and self-renewal capacity of CML CD34+ cells, increases p15INK4B and p27KIP1 but not p16INK4A and p57KIP2 expression; reduces growth of CML LSCs and prolongs survival of CML mice. |
| Name | N-[(9-Ethyl-9H-carbazol-3-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalenamine |
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| Synonym | More Synonyms |
| Description | PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8); markedly decreases BCR-ABL mRNA levels in both CD34+CD38-cells and CD34+CD38+ cells, reduces survival and self-renewal capacity of CML CD34+ cells, increases p15INK4B and p27KIP1 but not p16INK4A and p57KIP2 expression; reduces growth of CML LSCs and prolongs survival of CML mice. |
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| References | References 1. Jin Y, et al. J Clin Invest. 2016 Oct 3;126(10):3961-3980. 2. Kaushik S, et al. Leukemia. 2018 Feb;32(2):499-509. View Related Products by Target Histone Methyltransferase (HMTase) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 553.4±42.0 °C at 760 mmHg |
| Molecular Formula | C25H26N2 |
| Molecular Weight | 354.487 |
| Flash Point | 288.5±27.9 °C |
| Exact Mass | 354.209595 |
| LogP | 6.68 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.649 |
| N-[(9-Ethyl-9H-carbazol-3-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalenamine |
| 9H-Carbazole-3-methanamine, 9-ethyl-N-(1,2,3,4-tetrahydro-1-naphthalenyl)- |
| (9-Ethyl-9H-carbazol-3-ylmethyl)-(1,2,3,4-tetrahydro-naphthalen-1-yl)-amine |