352544-59-3

352544-59-3 structure

Name: PJ-68
Chemical Name: N-[(9-Ethyl-9H-carbazol-3-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalenamine
CAS Number: 352544-59-3
Molecular Formula: C₂₅H₂₆N₂
Molecular Weight: 354.487
Create Date: 2020-01-11 19:14:30
Modify Date: 2024-01-11 17:39:09
PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8); markedly decreases BCR-ABL mRNA levels in both CD34+CD38-cells and CD34+CD38+ cells, reduces survival and self-renewal capacity of CML CD34+ cells, increases p15INK4B and p27KIP1 but not p16INK4A and p57KIP2 expression; reduces growth of CML LSCs and prolongs survival of CML mice.

Name	N-[(9-Ethyl-9H-carbazol-3-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalenamine
Synonyms	N-[(9-Ethyl-9H-carbazol-3-yl)methyl]-1,2,3,4-tetrahydro-1-naphthalenamine 9H-Carbazole-3-methanamine, 9-ethyl-N-(1,2,3,4-tetrahydro-1-naphthalenyl)- (9-Ethyl-9H-carbazol-3-ylmethyl)-(1,2,3,4-tetrahydro-naphthalen-1-yl)-amine

Description	PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8); markedly decreases BCR-ABL mRNA levels in both CD34+CD38-cells and CD34+CD38+ cells, reduces survival and self-renewal capacity of CML CD34+ cells, increases p15INK4B and p27KIP1 but not p16INK4A and p57KIP2 expression; reduces growth of CML LSCs and prolongs survival of CML mice.
References	References 1. Jin Y, et al. J Clin Invest. 2016 Oct 3;126(10):3961-3980. 2. Kaushik S, et al. Leukemia. 2018 Feb;32(2):499-509. View Related Products by Target Histone Methyltransferase (HMTase)