9-AMINO-6-CHLORO-2-METHOXYACRIDINE

Modify Date: 2025-08-25 19:10:06

9-AMINO-6-CHLORO-2-METHOXYACRIDINE structure	Common Name	9-AMINO-6-CHLORO-2-METHOXYACRIDINE
	CAS Number	3548-09-2	Molecular Weight	258.70300
	Density	1.367g/cm3	Boiling Point	475.1ºC at 760mmHg
	Molecular Formula	C₁₄H₁₁ClN₂O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	241.2ºC
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of 9-AMINO-6-CHLORO-2-METHOXYACRIDINE

9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H+/solute antiport system[1].

Name	9-Amino-6-chloro-2-methoxyacridine
Synonym	More Synonyms

Description	9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H+/solute antiport system[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Carqueijeiro I, et al. Analytical and Fluorimetric Methods for the Characterization of the Transmembrane Transport of Specialized Metabolites in Plants. Methods Mol Biol. 2016;1405:121-135.

Density	1.367g/cm3
Boiling Point	475.1ºC at 760mmHg
Molecular Formula	C₁₄H₁₁ClN₂O
Molecular Weight	258.70300
Flash Point	241.2ºC
Exact Mass	258.05600
PSA	48.14000
LogP	4.21340
Index of Refraction	1.734
InChIKey	IHHSSHCBRVYGJX-UHFFFAOYSA-N
SMILES	COc1ccc2nc3cc(Cl)ccc3c(N)c2c1
Storage condition	-20°C

9-AMINO-6-CHLORO-2-METHOXYACRIDINE MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7330000

CHEMICAL NAME :: Acridine, 9-amino-3-chloro-7-methoxy-

CAS REGISTRY NUMBER :: 3548-09-2

BEILSTEIN REFERENCE NO. :: 0226315

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H11-Cl-N2-O

MOLECULAR WEIGHT :: 258.72

WISWESSER LINE NOTATION :: T C666 BNJ EG IZ LO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year: 28,1,1947

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H315-H319-H335-H351
Precautionary Statements	P261-P281-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn: Harmful;
Risk Phrases	R36/37/38
Safety Phrases	22-26-36
RIDADR	NONH for all modes of transport
RTECS	AR7330000
HS Code	2933990090

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Literature: Bonse, Susanne; Santelli-Rouvier, Christiane; Barbe, Jacques; Krauth-Siegel, R. Luise Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5448 - 5454

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Literature: Gemma, Sandra; Kukreja, Gagan; Tripaldi, Pierangela; Altarelli, Maria; Bernetti, Matteo; Franceschini, Silvia; Savini, Luisa; Campiani, Giuseppe; Fattorusso, Caterina; Butini, Stefania Tetrahedron Letters, 2008 , vol. 49, # 13 p. 2074 - 2077

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Precursor 4
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DownStream 1
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HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Target: Trypanothione reductase
External Id: CHEMBL878025

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Target: Calf thymus DNA
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Source: ChEMBL
Target: Methylated-DNA--protein-cysteine methyltransferase
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Name: HIV Cellular Data
Source: NIAID
Target: N/A
External Id: HIV Cellular Data

Name: Competitive inhibition of human recombinant MGMT expressed in Escherichia coli STAR B...
Source: ChEMBL
Target: Methylated-DNA--protein-cysteine methyltransferase
External Id: CHEMBL5144473

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Target: NON-PROTEIN TARGET
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Name: Binding affinity to calf thymus DNA assessed as intercalation by measuring dissociati...
Source: ChEMBL
Target: Calf thymus DNA
External Id: CHEMBL5144467

Name: Ionization state of the molecule at physiological pH was evaluated by potentiometry.
Source: ChEMBL
Target: N/A
External Id: CHEMBL634208

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MFCD00083236

6-chloro-2-methoxyacridin-9-amine

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Use of 9-AMINO-6-CHLORO-2-METHOXYACRIDINE

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