T-705RTP
Modify Date: 2024-02-04 16:21:56
T-705RTP structure
|
Common Name | T-705RTP | ||
|---|---|---|---|---|
| CAS Number | 356783-10-3 | Molecular Weight | 595.10 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H12FN3Na3O15P3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of T-705RTPT-705RTP sodium is a selective and GTP-competitive influenza virus RNA polymerase inhibitor with an IC50 of 0.14 μM and a Ki of 1.52 μM. T-705RTP sodium is the active triphosphate metabolite of T-705 and has potent anti-influenza virus activity[1][2]. |
| Name | T-705RTP sodium |
|---|
| Description | T-705RTP sodium is a selective and GTP-competitive influenza virus RNA polymerase inhibitor with an IC50 of 0.14 μM and a Ki of 1.52 μM. T-705RTP sodium is the active triphosphate metabolite of T-705 and has potent anti-influenza virus activity[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | T-705RTP sodium and T-705RMP are detected in MDCK cells treated with T-705. T-705RTP sodium inhibits influenza virus RNA polymerase activity in a dose-dependent and a GTP-competitive manner[1]. T-705RTP sodium inhibits the incorporation of ATP and GTP in a competitive manner with Ki values of 7.72 and 1.56 μM, respectively. T-705RTP sodium inhibits the incorporation of CTP in a mixed-type manner with a Ki value of 11.3 μM, and also inhibits the incorporation of UTP in a noncompetitive manner[2]. The incorporation of a single molecule of T-705RTP sodium (10-1000 μM) inhibits influenza virus RNA strand extension[2]. |
| References |
| Molecular Formula | C10H12FN3Na3O15P3 |
|---|---|
| Molecular Weight | 595.10 |