N-(Hydroxymethyl)nicotinamide

Modify Date: 2024-01-09 12:21:06

N-(Hydroxymethyl)nicotinamide Structure
N-(Hydroxymethyl)nicotinamide structure
Common Name N-(Hydroxymethyl)nicotinamide
CAS Number 3569-99-1 Molecular Weight 152.151
Density 1.3±0.1 g/cm3 Boiling Point 427.7±25.0 °C at 760 mmHg
Molecular Formula C7H8N2O2 Melting Point 152-154 °C(lit.)
MSDS USA Flash Point 212.5±23.2 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of N-(Hydroxymethyl)nicotinamide


N-(Hydroxymethyl)nicotinamide is an antimicrobic agent[1].

 Names

Name N-(hydroxymethyl)pyridine-3-carboxamide
Synonym More Synonyms

 N-(Hydroxymethyl)nicotinamide Biological Activity

Description N-(Hydroxymethyl)nicotinamide is an antimicrobic agent[1].
Related Catalog
References

[1]. Zhang HK, et, al. [Study on the synthesis of N-hydroxymethyl-nicotinamide]. Yao Xue Xue Bao. 1992; 27(8): 629-31.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 427.7±25.0 °C at 760 mmHg
Melting Point 152-154 °C(lit.)
Molecular Formula C7H8N2O2
Molecular Weight 152.151
Flash Point 212.5±23.2 °C
Exact Mass 152.058578
PSA 62.22000
LogP -0.80
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.569
Storage condition -20?C Freezer

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QS4476500
CHEMICAL NAME :
Nicotinamide, N-(hydroxymethyl)-
CAS REGISTRY NUMBER :
3569-99-1
BEILSTEIN REFERENCE NO. :
0128633
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H8-N2-O2
MOLECULAR WEIGHT :
152.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 305,427,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 17,73,1960

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS QS4476500
HS Code 2933399090

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles2

More Articles
[Study on the synthesis of N-hydroxymethyl-nicotinamide].

Yao Xue Xue Bao 27(8) , 629-31, (1992)

N-Hydroxymethyl-nicotinamide, an antimicrobic agent was prepared in good yield by treating nicotinamide with excess of formaldehyde in the presence of potassium carbonate. The condensation reaction wa...

Thin-layer chromatography-densitometric measurements for determination of N-(hydroxymethyl)nicotinamide in tablets and stability evaluation in solutions.

J. AOAC Int. 91(5) , 1186-90, (2008)

A thin-layer chromatography (TLC)-densitometric method was developed to determine N-(hydroxymethyl)nicotinamide in tablets and basic solutions along with nicotinic acid. Analysis was performed on sili...

 Synonyms

Pyridine-3-carboxylic Acid N-Methylolamide
3-Pyridinecarboxamide, N-(hydroxymethyl)-
Nicodine
Bilizorin
Cholamid
EINECS 222-668-4
Bilamid
3-Pyridinecarboxylic acid N-hydroxymethylamide
Nicoform
Cholamide
MFCD00010437
Nikomethamide
N-(hydroxymethyl)pyridine-3-carboxamide
Bilocid
N-(Hydroxymethyl)nicotinamide
Nicodin
hydroxymethylnicotinamide
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