Seletracetam

Modify Date: 2024-01-08 11:08:37

Seletracetam Structure
Seletracetam structure
Common Name Seletracetam
CAS Number 357336-74-4 Molecular Weight 232.22700
Density N/A Boiling Point N/A
Molecular Formula C10H14F2N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Seletracetam


Seletracetam (Ucb 44212) is an analog of the antiepileptic agent Levetiracetam. Seletracetam is a small molecule SV2A modulator for the research of epilepsy[1][2][3].

 Names

Name (2S)-2-[(4S)-4-(2,2-difluoroethenyl)-2-oxopyrrolidin-1-yl]butanamide
Synonym More Synonyms

 Seletracetam Biological Activity

Description Seletracetam (Ucb 44212) is an analog of the antiepileptic agent Levetiracetam. Seletracetam is a small molecule SV2A modulator for the research of epilepsy[1][2][3].
Related Catalog
Target

SV2A[1]

In Vitro Seletracetam decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle protein SV2A[2]. Seletracetam decreases synaptic responses in a time-, frequency- and concentration-dependent manner[2]. Seletracetam modifies rates of presynaptic release[2]. Seletracetam inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro[2].
References

[1]. Pollard JR, et al. Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy. Curr Opin Investig Drugs. 2008 Jan;9(1):101-7.

[2]. Yang X, et al. Seletracetam enhances short term depression in vitro. Epilepsy Res. 2015 Nov;117:17-22.

[3]. Martella G, et al. Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. Epilepsia. 2009 Apr;50(4):702-10.

 Chemical & Physical Properties

Molecular Formula C10H14F2N2O2
Molecular Weight 232.22700
Exact Mass 232.10200
PSA 64.39000
LogP 1.96680

 Safety Information

HS Code 2933790090

 Customs

HS Code 2933790090
Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

 Synonyms

UNII-RFR2CH3QZK
Seletracetam
Seletracetam (USAN/INN)
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