357336-74-4

357336-74-4 structure

Name: Seletracetam
Chemical Name: (2S)-2-[(4S)-4-(2,2-difluoroethenyl)-2-oxopyrrolidin-1-yl]butanamide
CAS Number: 357336-74-4
Molecular Formula: C₁₀H₁₄F₂N₂O₂
Molecular Weight: 232.22700
Catalog: Research Areas Neurological Disease
Create Date: 2017-05-13 01:26:21
Modify Date: 2024-01-08 11:08:37
Seletracetam (Ucb 44212) is an analog of the antiepileptic agent Levetiracetam. Seletracetam is a small molecule SV2A modulator for the research of epilepsy[1][2][3].

Name	(2S)-2-[(4S)-4-(2,2-difluoroethenyl)-2-oxopyrrolidin-1-yl]butanamide
Synonyms	UNII-RFR2CH3QZK Seletracetam Seletracetam (USAN/INN)

Description	Seletracetam (Ucb 44212) is an analog of the antiepileptic agent Levetiracetam. Seletracetam is a small molecule SV2A modulator for the research of epilepsy[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	SV2A[1]
In Vitro	Seletracetam decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle protein SV2A[2]. Seletracetam decreases synaptic responses in a time-, frequency- and concentration-dependent manner[2]. Seletracetam modifies rates of presynaptic release[2]. Seletracetam inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro[2].
References	[1]. Pollard JR, et al. Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy. Curr Opin Investig Drugs. 2008 Jan;9(1):101-7. [2]. Yang X, et al. Seletracetam enhances short term depression in vitro. Epilepsy Res. 2015 Nov;117:17-22. [3]. Martella G, et al. Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. Epilepsia. 2009 Apr;50(4):702-10.

HS Code	2933790090

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%