N-p-trans-Coumaroyltyramine

Modify Date: 2024-01-06 16:33:13

N-p-trans-Coumaroyltyramine structure	Common Name	N-p-trans-Coumaroyltyramine
	CAS Number	36417-86-4	Molecular Weight	283.322
	Density	1.2±0.1 g/cm3	Boiling Point	586.5±50.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₇NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	308.5±30.1 °C

Use of N-p-trans-Coumaroyltyramine

N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 µM for T. brucei rhodesiense[1][2].

Name	(2E)-3-(4-Hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]acrylamide
Synonym	More Synonyms

Description	N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 µM for T. brucei rhodesiense[1][2].
Related Catalog	Research Areas >> Infection Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 122 μM (AChE)[2]
References	[1]. Moradi-Afrapoli F, et al. Cinnamoylphenethyl amides from Polygonum hyrcanicum possess anti-trypanosomal activity. Nat Prod Commun. 2012 Jun;7(6):753-5. [2]. Kim DK, et al. Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase. Arch Pharm Res. 2003 Sep;26(9):735-8.

Density	1.2±0.1 g/cm3
Boiling Point	586.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₇NO₃
Molecular Weight	283.322
Flash Point	308.5±30.1 °C
Exact Mass	283.120850
PSA	69.56000
LogP	2.24
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.655
Storage condition	2-8℃