2′-Deoxyuridine-C,N2

Modify Date: 2023-01-16 17:47:12

2′-Deoxyuridine-C,N2 Structure
2′-Deoxyuridine-C,N2 structure
Common Name 2′-Deoxyuridine-C,N2
CAS Number 369656-76-8 Molecular Weight 228.202
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C9H12N2O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2′-Deoxyuridine-C,N2


2'-Deoxyuridine-13C,15N2 is the 13C and 15N labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].

 Names

Name 2'-Deoxyuridine-13C,15N2
Synonym More Synonyms

 2′-Deoxyuridine-C,N2 Biological Activity

Description 2'-Deoxyuridine-13C,15N2 is the 13C and 15N labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Reidy JA, et al. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26(1):1-5.  

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C9H12N2O5
Molecular Weight 228.202
Exact Mass 228.074615
PSA 104.55000
LogP -1.70
Index of Refraction 1.603
Storage condition -20°C

 Synonyms

2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-threo-pentofuranosyl)-
1-(2-Deoxy-β-D-threo-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione
1-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
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