bleomycin A6

Modify Date: 2024-01-16 16:42:31

bleomycin A6 Structure
bleomycin A6 structure
 Common Name bleomycin A6
CAS Number 37293-17-7 Molecular Weight 1497.66000
Density 1.53g/cm3 Boiling Point N/A
Molecular Formula C60H96N20O21S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of bleomycin A6


Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis[1][2][3].

 Names

Name bleomycin A6
Synonym More Synonyms

 bleomycin A6 Biological Activity

Description Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis[1][2][3].
Related Catalog
In Vitro Boanmycin (50-125 μg/mL, 0.5-36 h) can induce apoptosis and block the cell cycle in the G2/M phase in Eca-109 cells[2]. Boanmycin (6.7 µg/mL, 24 h) induces cell senescence[3]. Cell Viability Assay[3] Cell Line: Human lung fibroblast cell line IMR90, mouse primary osteoblasts (OBs) Concentration: 6.7 µg/mL Incubation Time: 24 hours Result: Showed a 90% positive number of SA-βgal stained cells in IMR90 cells and 95% in OBs compared to 30% in the control group. RT-PCR[3] Cell Line: Mouse primary osteoblasts (OBs) Concentration: 6.7 µg/mL Incubation Time: 24 hours Result: Increased senescence-associated secretory phenotype (SASP) factor IL-6 expression up to six-fold.
In Vivo Boanmycin (BAM) (i.p., 10 or 15 mg/kg, twice a week, 5 weeks)can effectively inhibit the growth of tumors in BALB/c nude mice with HT-29, Hce-8693 or CT-26 cells[1]. Animal Model: BALB/c nude mice with HT-29 or Hce-8693 cells[1] Dosage: 10 or 15 mg/kg Administration: Intraperitoneal injection; twice a week; 5 weeks Result: Significantly inhibited tumor growth by 89% at 10 mg/kg and by 92% at 15 mg/kg in mice with HT-29 model, also inhibited tumor growth by 90% at 10 mg/kg and by 92% at 15 mg/kg in mice with Hce-8693 model. Animal Model: BALB/c nude mice with CT-26 cells[1] Dosage: 10 mg/kg Administration: Intramuscular injection; every second day; 10 times Result: Inhibited subcutaneous tumor growth by 88% and cecal tumor by 99%.
References

[1]. Y C Deng, et al. Activity of boanmycin against colorectal cancer. World J Gastroenterol. 2001 Feb;7(1):93-7.

[2]. Hao Tang, et al. Effect of boanmycin on apoptosis and cell cycle of human esophageal cancer(Eca-109) cells]. Ai Zheng. 2002 Aug;21(8):855-9.

[3]. Peng Chen, et al. The chemotherapeutic drug boanmycin induces cell senescence and senescence-associated secretory phenotype factors, thus acquiring the potential to remodel the tumor microenvironment. Anticancer Drugs. 2016 Feb;27(2):84-8.

 Chemical & Physical Properties

Density 1.53g/cm3
Molecular Formula C60H96N20O21S2
Molecular Weight 1497.66000
Exact Mass 1496.65000
PSA 733.63000

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EC5991325
CHEMICAL NAME :
Bleomycinamide, N(sup 1)-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-
CAS REGISTRY NUMBER :
37293-17-7
LAST UPDATED :
199607
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C60-H96-N20-O21-S2
MOLECULAR WEIGHT :
1497.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
102 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZKZAEY Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop. Rep. China) V.13- 1988- Volume(issue)/page/year: 15,453,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80330 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZKZAEY Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop. Rep. China) V.13- 1988- Volume(issue)/page/year: 15,453,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
97780 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZKZAEY Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop. Rep. China) V.13- 1988- Volume(issue)/page/year: 15,453,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
70530 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZKZAEY Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop. Rep. China) V.13- 1988- Volume(issue)/page/year: 15,453,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
24500 ug/kg/7W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
ZKZAEY Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop. Rep. China) V.13- 1988- Volume(issue)/page/year: 15,453,1990

 Synonyms

Zhengguangmycin A6
Pingyangmycin A6
N1-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]bleomycinamide
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