ASP 2535
Modify Date: 2024-04-05 17:00:59
ASP 2535 structure
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Common Name | ASP 2535 | ||
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| CAS Number | 374886-51-8 | Molecular Weight | 382.418 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 607.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C22H18N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 321.1±34.3 °C | |
Use of ASP 2535A potent, selective, brain permeable, orally available glycine transporter-1 (GlyT1) inhibitor with IC50 of 92 nM (rat GlyT1), 50-fold selectivity over GlyT2; shows minimal affinity for many other receptors except for μ-opioid receptors (IC50=1.83 uM); inhibits ex vivo [(3)H]-glycine uptake in mouse cortical homogenate, improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease. Schizophrenia Phase 1 Discontinued |
| Name | 4-[3-Isopropyl-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole |
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| Synonym | More Synonyms |
| Description | A potent, selective, brain permeable, orally available glycine transporter-1 (GlyT1) inhibitor with IC50 of 92 nM (rat GlyT1), 50-fold selectivity over GlyT2; shows minimal affinity for many other receptors except for μ-opioid receptors (IC50=1.83 uM); inhibits ex vivo [(3)H]-glycine uptake in mouse cortical homogenate, improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease. Schizophrenia Phase 1 Discontinued |
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| References | References 1. Harada K, et al. Eur J Pharmacol. 2012 Jun 15;685(1-3):59-69. View Related Products by Target Glycine Transporter (GlyT) Schizophrenia |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 607.3±65.0 °C at 760 mmHg |
| Molecular Formula | C22H18N6O |
| Molecular Weight | 382.418 |
| Flash Point | 321.1±34.3 °C |
| Exact Mass | 382.154205 |
| LogP | 5.09 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.717 |
| 2,1,3-Benzoxadiazole, 4-[3-(1-methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]- |
| 4-[3-Isopropyl-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole |