(6R)-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine

Modify Date: 2025-08-26 14:48:02

(6R)-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine Structure
(6R)-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine structure
Common Name (6R)-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine
CAS Number 380499-07-0 Molecular Weight 435.33500
Density N/A Boiling Point N/A
Molecular Formula C20H16F7NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Names

Name (6R)-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine

 Chemical & Physical Properties

Molecular Formula C20H16F7NO2
Molecular Weight 435.33500
Exact Mass 435.10700
PSA 30.82000
LogP 5.22210

 Synthetic Route

~90%

(6R)-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine Structure

(6R)-6-[(1R)-1-...

CAS#:380499-07-0

Literature: Sandoz AG Patent: WO2009/106486 A1, 2009 ; Location in patent: Page/Page column 15; 4 ;

~%

(6R)-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine Structure

(6R)-6-[(1R)-1-...

CAS#:380499-07-0

Literature: Zhao, Matthew M.; McNamara, James M.; Ho, Guo-Jie; Emerson, Khateeta M.; Song, Zhiguo J.; Tschaen, David M.; Brands, Karel M. J.; Dolling, Ulf-H; Grabowski, Edward J. J.; Reider, Paul J.; Cottrell, Ian F.; Ashwood, Michael S.; Bishop, Brian C. Journal of Organic Chemistry, 2002 , vol. 67, # 19 p. 6743 - 6747

~%

(6R)-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine Structure

(6R)-6-[(1R)-1-...

CAS#:380499-07-0

Literature: Zhao, Matthew M.; McNamara, James M.; Ho, Guo-Jie; Emerson, Khateeta M.; Song, Zhiguo J.; Tschaen, David M.; Brands, Karel M. J.; Dolling, Ulf-H; Grabowski, Edward J. J.; Reider, Paul J.; Cottrell, Ian F.; Ashwood, Michael S.; Bishop, Brian C. Journal of Organic Chemistry, 2002 , vol. 67, # 19 p. 6743 - 6747

~%

(6R)-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine Structure

(6R)-6-[(1R)-1-...

CAS#:380499-07-0

Literature: Zhao, Matthew M.; McNamara, James M.; Ho, Guo-Jie; Emerson, Khateeta M.; Song, Zhiguo J.; Tschaen, David M.; Brands, Karel M. J.; Dolling, Ulf-H; Grabowski, Edward J. J.; Reider, Paul J.; Cottrell, Ian F.; Ashwood, Michael S.; Bishop, Brian C. Journal of Organic Chemistry, 2002 , vol. 67, # 19 p. 6743 - 6747

~%

(6R)-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine Structure

(6R)-6-[(1R)-1-...

CAS#:380499-07-0

Literature: Zhao, Matthew M.; McNamara, James M.; Ho, Guo-Jie; Emerson, Khateeta M.; Song, Zhiguo J.; Tschaen, David M.; Brands, Karel M. J.; Dolling, Ulf-H; Grabowski, Edward J. J.; Reider, Paul J.; Cottrell, Ian F.; Ashwood, Michael S.; Bishop, Brian C. Journal of Organic Chemistry, 2002 , vol. 67, # 19 p. 6743 - 6747
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