Glucose-conjugated MGMT inhibitor
Modify Date: 2024-01-08 10:02:31
Glucose-conjugated MGMT inhibitor structure
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Common Name | Glucose-conjugated MGMT inhibitor | ||
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| CAS Number | 382607-78-5 | Molecular Weight | 616.52500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H34BrN5O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Glucose-conjugated MGMT inhibitorGlucose-conjugated MGMT inhibitor is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. |
| Name | (2R,3R,4S,5S,6R)-2-[8-[2-amino-6-[(4-bromothiophen-2-yl)methoxy]purin-9-yl]octoxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
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| Synonym | More Synonyms |
| Description | Glucose-conjugated MGMT inhibitor is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. |
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| Related Catalog | |
| Target |
MGMT:32 nM (IC50) |
| In Vitro | Glucose-conjugated MGMT inhibitor (O6BTG-octylglucoside) is a potent and non-toxic MGMT inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells[1]. |
| Kinase Assay | For the assays, 100 mg cell extract protein are used. In each assay, a negative and a positive sample, HeLa MR (MGMT-deficient) and HeLa S3 cell extract, respectively, are included. Incubation occurs in buffer contain-ing 700 mM HEPES-KOH (pH 7.8), 10 mM dithiothreitol and 50 mM EDTA for 90 min, which is the optimal time span for the reaction to be completed. Data are expressed as femtomoles of radioactivity trans-ferred from 3H-methylnitrosourea-labeled DNA to protein per milligram of protein within Glucose-conjugated MGMT inhibitor[1]. |
| References |
| Molecular Formula | C24H34BrN5O7S |
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| Molecular Weight | 616.52500 |
| Exact Mass | 615.13600 |
| PSA | 207.20000 |
| LogP | 1.89870 |
| Storage condition | 2-8℃ |
| Glucose-conjugated MGMT inhibitor |
| CS-0463 |