Karacoline

Modify Date: 2024-01-08 06:14:00

Karacoline Structure
Karacoline structure
 Common Name Karacoline
CAS Number 39089-30-0 Molecular Weight 377.518
Density 1.3±0.1 g/cm3 Boiling Point 540.2±50.0 °C at 760 mmHg
Molecular Formula C22H35NO4 Melting Point N/A
MSDS N/A Flash Point 280.5±30.1 °C

 Use of Karacoline


Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway[1].

 Names

Name karakoline
Synonym More Synonyms

 Karacoline Biological Activity

Description Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway[1].
Related Catalog
References

[1]. XiaoliZhou, et al. Karacoline, identified by network pharmacology, reduces degradation of the extracellular matrix in intervertebral disc degeneration via the NF-κB signaling pathway. Journal of Pharmaceutical Analysis, 2019.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 540.2±50.0 °C at 760 mmHg
Molecular Formula C22H35NO4
Molecular Weight 377.518
Flash Point 280.5±30.1 °C
Exact Mass 377.256622
PSA 73.16000
LogP -0.26
Vapour Pressure 0.0±3.3 mmHg at 25°C
Index of Refraction 1.623

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AR5569480
CHEMICAL NAME :
Aconitane-1,8,14-triol, 20-ethyl-16-methoxy-4-methyl-, (1-alpha,14-alpha,16-beta)-
CAS REGISTRY NUMBER :
39089-30-0
LAST UPDATED :
199412
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C22-H35-N-O4
MOLECULAR WEIGHT :
377.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
298 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
51500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

 Safety Information

RTECS AR5569480

 Synonyms

(1α,14α,16β)-20-Ethyl-16-methoxy-4-methylaconitane-1,8,14-triol
Karacoline
Karakoline
20-Ethyl-16-β-methoxy-4-methylaconitane-1-α,8,14-α-triol
Aconitane-1,8,14-triol, 20-ethyl-16-methoxy-4-methyl-, (1α,14α,16β)-
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Chemsrc provides Karacoline(CAS#:39089-30-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Karacoline are included as well.>> amp version: Karacoline

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