WAY-388264-A

Modify Date: 2024-02-04 17:41:23

WAY-388264-A structure	Common Name	WAY-388264-A
	CAS Number	393129-91-4	Molecular Weight	296.17
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₄BrN₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of WAY-388264-A

5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease[1][2].

Name	5-HT2B antagonist-1

Description	5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT2B Receptor:33.4 nM (IC50)
In Vitro	5-HT2B antagonist-1 (compound 5g) has some sodium channel binding activity with IC50 values in the range of 12.6 to 57.5 μM[1]. 5-HT2B antagonist-1 (coumpound 1-e) inhibits 5-HT2B receptor activity by less than 50% at 1 μM in CHO-K1 cell lines[3].
In Vivo	5-HT2B antagonist-1 (compound 15) (oral gavage, 30 mg/kg) can reduce visceral hypersensitivity significantly in irritable bowel syndrome (IBS) rats[2].
References	[1]. Xiang Ma, et al. Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5644 [2]. Yu Zhou, et al. Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome. J Med Chem. 2016 Jan 28;59(2):707-20. [3]. Huang Niu, et al. 5-HT2B Antagonists. WO2015158214

Molecular Formula	C₁₁H₁₄BrN₅
Molecular Weight	296.17
Storage condition	2-8°C

WAY-388264-A

Use of WAY-388264-A

Names

WAY-388264-A Biological Activity

Chemical & Physical Properties