2H-1,3,2-Oxazaphosphorin-2-amine,N,3-bis(2-chloroethyl)tetrahydro-4-hydroperoxy-, 2-oxide

Modify Date: 2025-09-18 10:11:27

2H-1,3,2-Oxazaphosphorin-2-amine,N,3-bis(2-chloroethyl)tetrahydro-4-hydroperoxy-, 2-oxide structure	Common Name	2H-1,3,2-Oxazaphosphorin-2-amine,N,3-bis(2-chloroethyl)tetrahydro-4-hydroperoxy-, 2-oxide
	CAS Number	39800-28-7	Molecular Weight	293.08
	Density	1.46g/cm3	Boiling Point	419.9ºC at 760mmHg
	Molecular Formula	C₇H₁₅Cl₂N₂O₄P	Melting Point	N/A
	MSDS	N/A	Flash Point	207.8ºC

Use of 2H-1,3,2-Oxazaphosphorin-2-amine,N,3-bis(2-chloroethyl)tetrahydro-4-hydroperoxy-, 2-oxide

4-Hydroperoxyifosfamide is an anticancer agent that can penetrate the blood-brain barrier (BBB)[1].

Name	4-hydroperoxyifosfamide
Synonym	More Synonyms

Description	4-Hydroperoxyifosfamide is an anticancer agent that can penetrate the blood-brain barrier (BBB)[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Ishimoto TM, et al. Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli. Pharmacogenetics. 2002 Oct;12(7):543-53.

Density	1.46g/cm3
Boiling Point	419.9ºC at 760mmHg
Molecular Formula	C₇H₁₅Cl₂N₂O₄P
Molecular Weight	293.08
Flash Point	207.8ºC
Exact Mass	292.01500
PSA	80.84000
LogP	2.02850
Index of Refraction	1.525
InChIKey	YGZIWEZFFBPCLN-UHFFFAOYSA-N
SMILES	O=P1(NCCCl)OCCC(OO)N1CCCl

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX2435000

CHEMICAL NAME :: Hydroperoxide, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro- 2H-1,3,2-oxazaphospho rin- 4-yl-, P-oxide

CAS REGISTRY NUMBER :: 39800-28-7

LAST UPDATED :: 199310

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H15-Cl2-N2-O4-P

MOLECULAR WEIGHT :: 293.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976

Hydroperoxyisophosphamide

4-Hydroperoxyisophosphamid

4-Hydroperoxyifosfamid

asta6760

4-hydroperoxyisophosphamide

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