Ceftaroline fosamil
Modify Date: 2024-01-03 18:20:07
Ceftaroline fosamil structure
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Common Name | Ceftaroline fosamil | ||
|---|---|---|---|---|
| CAS Number | 400827-46-5 | Molecular Weight | 744.74 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H25N8O10PS4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ceftaroline fosamilCeftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). |
| Name | ceftaroline fosamil acetate |
|---|---|
| Synonym | More Synonyms |
| Description | Ceftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). |
|---|---|
| Related Catalog | |
| In Vivo | Ceftaroline fosamil is effective against all 10 MRSA isolates used in the dose-ranging studies and requires approximately 17 to 43% fT>MIC (the percentage of time that free drug concentrations remain above the MIC) to produce a 1-log10 kill[1]. The Ceftaroline Fosamil treatment results in mean reductions of 1.1 to 2.4 log10 CFU, with no relationship to the Ceftaroline Fosamil MIC. The use of high inocula does not affect the Ceftaroline Fosamil efficacy against the three strains tested, with mean decreases of 2.0 to 3.0 log10 CFU[2]. |
| Animal Admin | Seventeen clinical S. aureus isolates (2 MSSA, 15 MRSA) are studied using the neutropenic lung infection model. Beginning 3 h after inoculation, groups of six mice receive treatment with Ceftaroline fosamil over a 24 h period. Ceftaroline fosamil doses are administered as 0.2 mL subcutaneous injections. Control animals are administered normal saline at the same volume, route, and frequency as the treatment regimens[1]. |
| References |
| Molecular Formula | C24H25N8O10PS4 |
|---|---|
| Molecular Weight | 744.74 |
| PSA | 346.85000 |
| LogP | -2.84 |
| Storage condition | 2-8℃ |
| Teflaro |
| (6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,acetate |
| Ceftaroline fosamil |
| PPI 0903 |
| (6R,7R)-7-({(2E)-2-(Ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl}amino)-3-{[4-(1-methyl-4-pyridiniumyl)-1,3-thiazol-2-yl]sulfanyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Ceftaroline fosamil acetate anhydrous |
| Pyridinium, 4-[2-[[(6R,7R)-2-carboxy-7-[[(2E)-2-(ethoxyimino)-1-oxo-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]ethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-, inner salt |
| UNII-EZ9W6O5S09 |
| Zinforo |
| Ceftaroline fosamil acetate |
| TAK-599 |