T62
T62 structure
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Common Name | T62 | ||
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| CAS Number | 40312-34-3 | Molecular Weight | 291.79600 | |
| Density | 1.337g/cm3 | Boiling Point | 527ºC at 760 mmHg | |
| Molecular Formula | C15H14ClNOS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 272.5ºC | |
Use of T62Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3]. |
| Name | (2-amino-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-(4-chlorophenyl)methanone |
|---|---|
| Synonym | More Synonyms |
| Description | Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3]. |
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| Related Catalog | |
| Target |
Adenosine A1 receptor[1] |
| In Vivo | Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level[1]. Animal Model: Male SpragueDawley rats (250 g) after paw incision surgery[1] Dosage: 0.3 μg, 0.5 μg, 1 μg, and 3 μg Administration: Intrathecal administration Result: Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) was 0.77 (0.63-0.91) μg. |
| References |
| Density | 1.337g/cm3 |
|---|---|
| Boiling Point | 527ºC at 760 mmHg |
| Molecular Formula | C15H14ClNOS |
| Molecular Weight | 291.79600 |
| Flash Point | 272.5ºC |
| Exact Mass | 291.04800 |
| PSA | 71.33000 |
| LogP | 4.67470 |
| Index of Refraction | 1.658 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2934999090 |
![(2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(4-chloro-3,5-diiodophenyl)methanone structure](https://image.chemsrc.com/caspic/079/880359-28-4.png)
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism.
J. Pharmacol. Exp. Ther. 305 , 950-955, (2003) Activation of adenosine A1 receptors by endogenous adenosine or synthetic agonists produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory a... |
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Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain.
Anesthesiology 100(4) , 956-61, (2004) The positive allosteric adenosine receptor modulator, T62 (2-amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene), has been shown to reduce mechanical allodynia in a rat model of neuropathic pa... |
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Allosteric modulation of G protein-coupled receptors: perspectives and recent developments.
Drug Discov. Today 9 , 752-758, (2004) Allosteric modulation of G protein-coupled receptors has recently been recognized as an alternative approach to gain selectivity in drug action. In this overview, allosteric modulators that enhance or... |
| 2-Amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene |
| UNII-9Q765ZIF8L |
| (2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(4-chlorophenyl)methanone |
| T62 |
| (2-amino-4,5,6,7-tetrahydro-1-benzothien-3-yl)(4-chlorophenyl)methanone |