UNII:43B0856528

Modify Date: 2024-01-01 19:16:39

UNII:43B0856528 Structure
UNII:43B0856528 structure
Common Name UNII:43B0856528
CAS Number 4098-71-9 Molecular Weight 222.283
Density 1.1±0.1 g/cm3 Boiling Point 286.9±13.0 °C at 760 mmHg
Molecular Formula C12H18N2O2 Melting Point -60°C
MSDS Chinese USA Flash Point 116.0±25.2 °C
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger

 Names

Name isophorone diisocyanate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 286.9±13.0 °C at 760 mmHg
Melting Point -60°C
Molecular Formula C12H18N2O2
Molecular Weight 222.283
Flash Point 116.0±25.2 °C
Exact Mass 222.136826
PSA 58.86000
LogP 4.67
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.520
Stability Reacts with all substances containing active hydrogen, such as acids, amines, water, phenols, mercaptans, amides, urea. Probably moisture sensitive.
Water Solubility <0.1 g/100 mL at 25 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NQ9370000
CHEMICAL NAME :
Isocyanic acid, methylene(3,5,5-trimethyl-3,1-cyclohexylene) ester
CAS REGISTRY NUMBER :
4098-71-9
LAST UPDATED :
199712
DATA ITEMS CITED :
24
MOLECULAR FORMULA :
C12-H18-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4825 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530238
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
123 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,334(86),1986
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528418
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528418
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528418
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
118 mg/m3/1H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0543418 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1370 ug/m3/4H/4W-I
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0528418 *** REVIEWS *** ACGIH TLV-TWA 0.045 mg/m3 (0.005 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-BELGIUM:TWA 0.005 ppm (0.045 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 0.005 ppm (0.045 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 0.010 ppm (0.09 mg/m3);STEL 0.020 ppm JAN 1993 OEL-GERMANY:TWA 0.01 ppm (0.09 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.01 ppm (0.09 mg/m3);Skin JAN 1993 OEL-SWEDEN:TWA 0.005 ppm (0.05 mg/m3);STEL 0.01 ppm (0.09 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.01 ppm (0.09 mg/m3);STEL 0.02 ppm JAN 1993 OEL-UNITED KINGDOM:TWA 0.02 mg/m3;STEL 0.07 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO IPDI-air:10H TWA 0.005 ppm (Sk);STEL 0.02 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83571 No. of Facilities: 111 (estimated) No. of Industries: 4 No. of Occupations: 19 No. of Employees: 3441 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83571 No. of Facilities: 1186 (estimated) No. of Industries: 15 No. of Occupations: 16 No. of Employees: 7245 (estimated) No. of Female Employees: 682 (estimated)

 Safety Information

Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H315-H317-H319-H330-H334-H335-H411
Precautionary Statements P260-P280-P284-P304 + P340 + P310-P342 + P311-P403 + P233
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic;N:Dangerousfortheenvironment;
Risk Phrases R22;R36/37/38;R42/43;R51/53
Safety Phrases S26-S28-S38-S45-S61
RIDADR UN 2290 6.1/PG 3
WGK Germany 2
RTECS NQ9370000
Packaging Group III
Hazard Class 6.1
HS Code 2929109000

 Customs

HS Code 2929109000
Summary 2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl Isocyanate
5-Isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane
Isophorone diisocyanate
Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl-
EINECS 223-861-6
UNII:43B0856528
MFCD00064956
IPDI
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