R-(-)-Apomorphine

Apomorphine Hydrochloride, hemihydrate

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Section 3. Hazards Identification
Hazardous in case of ingestion, of inhalation (lung sensitizer). Slightly hazardous in case of skin contact (irritant,
Potential Acute Health
sensitizer), of eye contact (irritant).
Effects
CARCINOGENIC EFFECTS: Not available.
Potential Chronic Health
MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
Effects
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
The substance may be toxic to kidneys, gastrointestinal tract, central nervous system (CNS).
Repeated or prolonged exposure to the substance can produce target organs damage.

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Section 4. First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
Eye Contact
15 minutes. Cold water may be used. Get medical attention if irritation occurs.
Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Skin Contact
Cold water may be used.
Not available.
Serious Skin Contact
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
Inhalation
medical attention.
Not available.
Serious Inhalation
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
Ingestion
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Not available.
Serious Ingestion

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Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Not available.
Flash Points
Not available.
Flammable Limits
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds.
Products of Combustion
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Non-flammable in presence of shocks.
Various Substances
Slightly explosive in presence of open flames and sparks.
Explosion Hazards in
Non-explosive in presence of shocks.
Presence of Various
Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
As with most organic solids, fire is possible at elevated temperatures
Special Remarks on
Fire Hazards
Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust
Special Remarks on
explosion hazard.
Explosion Hazards
Apomorphine Hydrochloride, hemihydrate

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Section 6. Accidental Release Measures
Use appropriate tools to put the spilled solid in a convenient waste disposal container. If necessary: Neutralize the
Small Spill
residue with a dilute solution of sodium carbonate. Finish cleaning by spreading water on the contaminated
surface and dispose of according to local and regional authority requirements.
Use a shovel to put the material into a convenient waste disposal container. Neutralize the residue with a dilute
Large Spill
solution of sodium carbonate. Finish cleaning by spreading water on the contaminated surface and allow to
evacuate through the sanitary system.

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Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. Do not breathe dust. Wear suitable protective clothing.
Precautions
In case of insufficient ventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and
show the label when possible. Keep away from incompatibles such as oxidizing agents, alkalis.
Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in
Storage
light-resistant containers. Air Sensitive

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Section 8. Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
Engineering Controls
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to
avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE
of a Large Spill
handling this product.
Not available.
Exposure Limits

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Section 9. Physical and Chemical Properties
Solid. (Crystalline powder.)Odorless.
Physical state andO dor
appearance
Not available.
Taste
312.8 g/mole
Molecular Weight
White. Off-white.
Color
4 - 5[Acidic.]
pH (1% soln/water)
Not available.
Boiling Point
195°C (383°F)
Melting Point
Not available.
Critical Temperature
Not available.
Specific Gravity
Not applicable.
Vapor Pressure
Not available.
Vapor Density
Not available.
Volatility
Not available.
Odor Threshold
Not available.
Water/Oil Dist. Coeff.
Not available.
Ionicity (in Water)
See solubility in water.
Dispersion Properties
Soluble in cold water.
Solubility
Slightly soluble in diethyl ether.
Solubility in water: 20 g/l
Insoluble in chloroform.
Apomorphine Hydrochloride, hemihydrate

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Section 10. Stability and Reactivity Data
The product is stable.
Stability
Not available.
Instability Temperature
Conditions of Instability Excess heat, incompatible materials, dust generation
Incompatibility with various Reactive with oxidizing agents, alkalis.
substances
Not available.
Corrosivity
Air and light sensitive.
Special Remarks on
Incompatible with iodides, tannin, iron salts
Reactivity
Not available.
Special Remarks on
Corrosivity
Will not occur.
Polymerization

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Section 11. Toxicological Information
Inhalation. Ingestion.
Routes of Entry
Acute oral toxicity (LD50): 300 mg/kg [Mouse].
Toxicity to Animals
Chronic Effects on Humans MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
May cause damage to the following organs: kidneys, gastrointestinal tract, central nervous system (CNS).
Other Toxic Effects onHazardous in case of ingestion, of inhalation (lung sensitizer).
HumansSlightly hazardous in case of skin contact (irritant, sensitizer).
Not available.
Special Remarks on
Toxicity to Animals
May affect genetic material (mutagenic).
Special Remarks on
Chronic Effects on Humans May cause adverse reproductive effects based on animal test data
Special Remarks on otherAcute Potential Health Effects:
Toxic Effects on HumansSkin: Skin contact may cause redness, irritation and sensitization. Absorption through skin (e.g. by subcutaneous
injection will produce systemic and central nervous symtpoms similar that of ingestion or inhalation.
Eyes: May cause redness, and irritation.
Inhalation: Inhalation of dust may cause sensitization, asthma, and respiratory tract irritation. Inhalation of dust may
also cause nausea, and vomiting, and may affect behavior/central nervous system (symptoms similar to that of
ingestion)
Ingestion: May be harmful if swallowed. Causes gastrointestinal tract irritation with abdominal pain, nausa, vomiting
and diarrhea. May affect behavior/central nervous system and cause stimulation and depression of the central
nervous system. Symptoms may include restlessness, euphoria, drowsiness or sleepiness, yawning, somnolence,
dizziness, sedation, cognitive impairment, personality change, lightheadedness, tremors, confusion, halllucinations,
coma/unconsciousness. Other symptoms may include pin point or dilated pupils, respiratory depression, postural
hypotension, sore throat, increased cough, rhihitis, flushing, taste disorder, sweating, circulatory failure, death. It may
also affect the kidneys.
Chronic Potential Health Effects:
Ingestion or Skin Absorption/Subcutaneous injection: Prolonged or repeated ingestion or exposure by subcutaneous
injection may have systemic and nervous system symptoms similar to that of acute ingestion or inhalation and affect
the kidneys, adrenal gland and cause loss of appetite/weight loss.

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Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Apomorphine Hydrochloride, hemihydrate
The products of degradation are more toxic than the product itself.
Toxicity of the Products
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation

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Section 13. Disposal Considerations
Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control
regulations.

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Section 14. Transport Information
Not a DOT controlled material (United States).
DO T Cl assi fi cati on
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DO T (Pi ctograms)

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Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
California prop. 65: This product contains the following ingredients for which the State of California has found to
California
cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause birth defects which would require a warning under the statute: No products were found.
Not available.
Other Regulations
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
R20/22- Harmful by inhalation and ifS24- Avoid contact with skin.
DSCL (EEC)
swallowed.S36/37- Wear suitable protective clothing and
R42/43- May cause sensitization bygloves.
inhalation and skin contact.S46- If swallowed, seek medical advice
immediately and show this container or label.
Health Hazard
HMIS (U.S.A.)2 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
2 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal ProtectionE
WHMIS (Canada)
(Pictograms)
Apomorphine Hydrochloride, hemihydrate
DSCL (Europe)
(Pictograms)
TDG(Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or equivalent.

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SECTION 16 - ADDITIONAL INFORMATION
N/A